Mammalian runt-domain proteins and their roles in hematopoiesis, osteogenesis, and leukemia

Jennifer J Westendorf, Scott W. Hiebert

Research output: Contribution to journalArticle

119 Scopus citations

Abstract

Mammalian Runt-domain-containing factors are structurally and functionally similar and have essential roles in hematopoiesis and osteogenesis. These factors can act as either positive or negative transcriptional regulators of tissue-specific genes whose promoters or enhancers contain the consensus Runt-domain binding element, TGT/CGGT. This sequence is necessary but not sufficient to regulate the transcription of a wide variety of genes. Runt-domain factors are promoter organizers that cooperate with neighboring factors and recruit transcriptional co-activators or co-repressors to regulate expression of tissue-specific genes. AML1 is required for hematopoiesis and is a frequent target of chromosomal translocations in acute leukemias. Fusion proteins generated by these translocations are dominant repressors of genes regulated by the Runt-domain factors. AML3 may also be involved in leukemogenesis. In addition, AML3 has an essential role in bone development, as it is required for osteoblast differentiation and is mutated in patients with cleidocranial dysplasia.

Original languageEnglish (US)
Pages (from-to)51-58
Number of pages8
JournalJournal of Cellular Biochemistry
Volume76
Issue numberSUPPL. 32/33
StatePublished - 1999
Externally publishedYes

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Keywords

  • AML1
  • AML2
  • AML3
  • Bone
  • CBFA
  • Cleidocranial dysplasia
  • ETO
  • Leukemia
  • Osteoblasts
  • PEPB2α
  • Runx

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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