TY - JOUR
T1 - Mammalian RNA polymerases I and II
T2 - Independent diurnal variations in activity
AU - Glasser, Stanley R.
AU - Spelsberg, Thomas C.
N1 - Funding Information:
Supported by USPHS CA-13065-01, Ford Vanderbilt Center for Population Research
PY - 1972/5/26
Y1 - 1972/5/26
N2 - Diurnal variations in the activities of nucleolar (I) and non-nucleolar (II) DNA-dependent RNA polymerases of rat liver were observed. Both polymerase I and II displayed diphasic shifts in activity levels. However, the patterns of the individual shifts were not synchronous. Polymerase I activity was highest between 0100-1100 hours and lowest between 1700-2000 hours while polymerase II peaks between 2400 and 0500 hours with a low point at 1000 hours. The daily fluctuations and the dissimilar patterns of polymerase I and II activity may be of such significance as to require reevaluation and redesign of studies dealing with regulation of enzyme activity.
AB - Diurnal variations in the activities of nucleolar (I) and non-nucleolar (II) DNA-dependent RNA polymerases of rat liver were observed. Both polymerase I and II displayed diphasic shifts in activity levels. However, the patterns of the individual shifts were not synchronous. Polymerase I activity was highest between 0100-1100 hours and lowest between 1700-2000 hours while polymerase II peaks between 2400 and 0500 hours with a low point at 1000 hours. The daily fluctuations and the dissimilar patterns of polymerase I and II activity may be of such significance as to require reevaluation and redesign of studies dealing with regulation of enzyme activity.
UR - http://www.scopus.com/inward/record.url?scp=0015524754&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015524754&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(72)90585-2
DO - 10.1016/0006-291X(72)90585-2
M3 - Article
C2 - 4402075
AN - SCOPUS:0015524754
SN - 0006-291X
VL - 47
SP - 951
EP - 958
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 4
ER -