Malignant histiocytosis and encephalomyeloradiculopathy complicating coeliac disease

Michael Camilleri, T. Krausz, P. D. Lewis, H. J. Hodgson, C. A. Pallis, V. S. Chadwick

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A 62 year old Irish woman with an eight year history of probable coeliac disease developed brain stem signs, unilateral facial numbness and weakness, wasting and anaesthesia in both lower limbs. Over the next two years, a progressive deterioration in neurological function and in intestinal absorption, and the development of anaemia led to a suspicion of malignancy. Bone marrow biopsy revealed malignant histiocytosis. Treatment with cytotoxic drugs led to a transient, marked improvement in intestinal structure and function, and in power of the lower limbs. Relapse was associated with bone marrow failure, resulting in overwhelming infection. Post mortem examination confirmed the presence of an unusual demyelinating encephalomyelopathy affecting the brain stem and the posterior columns of the spinal cord.

Original languageEnglish (US)
Pages (from-to)441-447
Number of pages7
JournalGut
Volume24
Issue number5
StatePublished - 1983
Externally publishedYes

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Histiocytic Sarcoma
Celiac Disease
Brain Stem
Lower Extremity
Bone Marrow
Hypesthesia
Intestinal Absorption
Anemia
Autopsy
Spinal Cord
Anesthesia
Biopsy
Recurrence
Infection
Pharmaceutical Preparations
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Camilleri, M., Krausz, T., Lewis, P. D., Hodgson, H. J., Pallis, C. A., & Chadwick, V. S. (1983). Malignant histiocytosis and encephalomyeloradiculopathy complicating coeliac disease. Gut, 24(5), 441-447.

Malignant histiocytosis and encephalomyeloradiculopathy complicating coeliac disease. / Camilleri, Michael; Krausz, T.; Lewis, P. D.; Hodgson, H. J.; Pallis, C. A.; Chadwick, V. S.

In: Gut, Vol. 24, No. 5, 1983, p. 441-447.

Research output: Contribution to journalArticle

Camilleri, M, Krausz, T, Lewis, PD, Hodgson, HJ, Pallis, CA & Chadwick, VS 1983, 'Malignant histiocytosis and encephalomyeloradiculopathy complicating coeliac disease', Gut, vol. 24, no. 5, pp. 441-447.
Camilleri M, Krausz T, Lewis PD, Hodgson HJ, Pallis CA, Chadwick VS. Malignant histiocytosis and encephalomyeloradiculopathy complicating coeliac disease. Gut. 1983;24(5):441-447.
Camilleri, Michael ; Krausz, T. ; Lewis, P. D. ; Hodgson, H. J. ; Pallis, C. A. ; Chadwick, V. S. / Malignant histiocytosis and encephalomyeloradiculopathy complicating coeliac disease. In: Gut. 1983 ; Vol. 24, No. 5. pp. 441-447.
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