Making the case for objective performance metrics in newborn screening by tandem mass spectrometry

Piero Rinaldo, Saba Zafari, Silvia Tortorelli, Dietrich Matern

Research output: Contribution to journalReview article

46 Scopus citations

Abstract

The expansion of newborn screening programs to include multiplex testing by tandem mass spectrometry requires understanding and close monitoring of performance metrics. This is not done consistently because of lack of defined targets, and interlaboratory comparison is almost nonexistent. Between July 2004 and April 2006 (N = 176,185 cases), the overall performance metrics of the Minnesota program, limited to MS/MS testing, were as follows: detection rate 1:1,816, positive predictive value 37% (54% in 2006 till date), and false positive rate 0.09%. The repeat rate and the proportion of cases with abnormal findings actually been reported are new metrics proposed here as an objective mean to express the overall noise in a program, where noise is defined as the total number of abnormal results obtained using a given set of cut-off values. On the basis of our experience, we propose the following targets as evidence of adequate analytical and postanalytical performance: detection rate 1:3,000 or higher, positive predictive value >20%, and false positive rate <0.3%.

Original languageEnglish (US)
Pages (from-to)255-261
Number of pages7
JournalMental Retardation and Developmental Disabilities Research Reviews
Volume12
Issue number4
DOIs
StatePublished - Dec 1 2006

Keywords

  • Detection rate
  • False positive rate
  • Positive predictive value
  • Tandem mass spectrometry

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neuropsychology and Physiological Psychology
  • Genetics(clinical)

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