Major histocompatibility complex class II alleles and the course and outcome of MS: A population-based study

Brian G Weinshenker, P. Santrach, A. S. Bissonet, S. K. McDonnell, Daniel J Schaid, S. B. Moore, M. Rodriguez

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Abstract

Background: The major histocompatibility complex (MHC) has been consistently associated with susceptibility to MS and the course of several other human autoimmune diseases. A putative association between the course and severity of MS and the MHC remains controversial. Methods: DR and DQ genotyping by either restriction fragment length polymorphism or sequence- specific PCR-based typing in 119 patients representing 73.4% of the population with MS evaluated in a cross-sectional disability survey and 100 healthy controls from Olmsted County, Minnesota. Results: We found a positive association between MS susceptibility and the DR15-DQ6 and DR13-DQ7 haplotypes, and we found a negative association with the DR1-DQ5 haplotype. We found a trend to a positive association of primary progressive MS with DR4-DQ8 and DR1-DQ5 and an association of 'bout onset' MS with DR17-DQ2. We did not find an association with disease severity, as defined by EDSS/duration. Conclusion: Lack of consistency between different studies may be due to regional variation in MS and limitations of power but likely indicate a minor effect of MHC class II genes on the course and severity of MS.

Original languageEnglish (US)
Pages (from-to)742-747
Number of pages6
JournalNeurology
Volume51
Issue number3
StatePublished - Sep 1998

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Major Histocompatibility Complex
Alleles
Haplotypes
Population
MHC Class II Genes
Restriction Fragment Length Polymorphisms
Autoimmune Diseases
Cross-Sectional Studies
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Weinshenker, B. G., Santrach, P., Bissonet, A. S., McDonnell, S. K., Schaid, D. J., Moore, S. B., & Rodriguez, M. (1998). Major histocompatibility complex class II alleles and the course and outcome of MS: A population-based study. Neurology, 51(3), 742-747.

Major histocompatibility complex class II alleles and the course and outcome of MS : A population-based study. / Weinshenker, Brian G; Santrach, P.; Bissonet, A. S.; McDonnell, S. K.; Schaid, Daniel J; Moore, S. B.; Rodriguez, M.

In: Neurology, Vol. 51, No. 3, 09.1998, p. 742-747.

Research output: Contribution to journalArticle

Weinshenker, BG, Santrach, P, Bissonet, AS, McDonnell, SK, Schaid, DJ, Moore, SB & Rodriguez, M 1998, 'Major histocompatibility complex class II alleles and the course and outcome of MS: A population-based study', Neurology, vol. 51, no. 3, pp. 742-747.
Weinshenker, Brian G ; Santrach, P. ; Bissonet, A. S. ; McDonnell, S. K. ; Schaid, Daniel J ; Moore, S. B. ; Rodriguez, M. / Major histocompatibility complex class II alleles and the course and outcome of MS : A population-based study. In: Neurology. 1998 ; Vol. 51, No. 3. pp. 742-747.
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AU - Weinshenker, Brian G

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AU - Schaid, Daniel J

AU - Moore, S. B.

AU - Rodriguez, M.

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N2 - Background: The major histocompatibility complex (MHC) has been consistently associated with susceptibility to MS and the course of several other human autoimmune diseases. A putative association between the course and severity of MS and the MHC remains controversial. Methods: DR and DQ genotyping by either restriction fragment length polymorphism or sequence- specific PCR-based typing in 119 patients representing 73.4% of the population with MS evaluated in a cross-sectional disability survey and 100 healthy controls from Olmsted County, Minnesota. Results: We found a positive association between MS susceptibility and the DR15-DQ6 and DR13-DQ7 haplotypes, and we found a negative association with the DR1-DQ5 haplotype. We found a trend to a positive association of primary progressive MS with DR4-DQ8 and DR1-DQ5 and an association of 'bout onset' MS with DR17-DQ2. We did not find an association with disease severity, as defined by EDSS/duration. Conclusion: Lack of consistency between different studies may be due to regional variation in MS and limitations of power but likely indicate a minor effect of MHC class II genes on the course and severity of MS.

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