Maintaining the Health of the Renal Allograft: Laboratory and Histologic Monitoring After Kidney Transplantation

Carrie Schinstock, Manish J. Gandhi

Research output: Contribution to journalArticle

Abstract

Advances in posttransplant care, including new immunosuppressive medications have led to excellent short-term renal allograft survival. However, there is a small therapeutic window within which the patient and the clinician must balance the risk of rejection, with side effects such as infection, malignancy, and toxicity. Laboratory testing plays a key role in this ongoing monitoring, which includes relatively simple tests, such as serum creatinine, to complex tests, such as solid-phase assays, used to monitor for donor-specific antibody and surveillance allograft biopsies. This article reviews the role of the laboratory tests and surveillance biopsies in posttransplant monitoring.

Original languageEnglish (US)
JournalClinics in Laboratory Medicine
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Biopsy
Kidney Transplantation
Allografts
Health
Kidney
Monitoring
Immunosuppressive Agents
Toxicity
Assays
Creatinine
Tissue Donors
Antibodies
Testing
Infection
Serum
Neoplasms
Therapeutics

Keywords

  • De novo donor-specific antibodies
  • Posttransplant GFR
  • Posttransplant monitoring
  • Posttransplant proteinuria
  • Surveillance biopsy

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

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abstract = "Advances in posttransplant care, including new immunosuppressive medications have led to excellent short-term renal allograft survival. However, there is a small therapeutic window within which the patient and the clinician must balance the risk of rejection, with side effects such as infection, malignancy, and toxicity. Laboratory testing plays a key role in this ongoing monitoring, which includes relatively simple tests, such as serum creatinine, to complex tests, such as solid-phase assays, used to monitor for donor-specific antibody and surveillance allograft biopsies. This article reviews the role of the laboratory tests and surveillance biopsies in posttransplant monitoring.",
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