Maintaining the Health of the Renal Allograft: Laboratory and Histologic Monitoring After Kidney Transplantation

Carrie A. Schinstock; Manish J. Gandhi

doi:10.1016/j.cll.2018.07.003

Maintaining the Health of the Renal Allograft: Laboratory and Histologic Monitoring After Kidney Transplantation

Carrie A. Schinstock, Manish J. Gandhi

Nephrology and Hypertension

Research output: Contribution to journal › Review article › peer-review

Abstract

Advances in posttransplant care, including new immunosuppressive medications have led to excellent short-term renal allograft survival. However, there is a small therapeutic window within which the patient and the clinician must balance the risk of rejection, with side effects such as infection, malignancy, and toxicity. Laboratory testing plays a key role in this ongoing monitoring, which includes relatively simple tests, such as serum creatinine, to complex tests, such as solid-phase assays, used to monitor for donor-specific antibody and surveillance allograft biopsies. This article reviews the role of the laboratory tests and surveillance biopsies in posttransplant monitoring.

Original language	English (US)
Pages (from-to)	607-621
Number of pages	15
Journal	Clinics in Laboratory Medicine
Volume	38
Issue number	4
DOIs	https://doi.org/10.1016/j.cll.2018.07.003
State	Published - Dec 2018

Keywords

De novo donor-specific antibodies
Posttransplant GFR
Posttransplant monitoring
Posttransplant proteinuria
Surveillance biopsy

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

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title = "Maintaining the Health of the Renal Allograft: Laboratory and Histologic Monitoring After Kidney Transplantation",

abstract = "Advances in posttransplant care, including new immunosuppressive medications have led to excellent short-term renal allograft survival. However, there is a small therapeutic window within which the patient and the clinician must balance the risk of rejection, with side effects such as infection, malignancy, and toxicity. Laboratory testing plays a key role in this ongoing monitoring, which includes relatively simple tests, such as serum creatinine, to complex tests, such as solid-phase assays, used to monitor for donor-specific antibody and surveillance allograft biopsies. This article reviews the role of the laboratory tests and surveillance biopsies in posttransplant monitoring.",

keywords = "De novo donor-specific antibodies, Posttransplant GFR, Posttransplant monitoring, Posttransplant proteinuria, Surveillance biopsy",

author = "Schinstock, {Carrie A.} and Gandhi, {Manish J.}",

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year = "2018",

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doi = "10.1016/j.cll.2018.07.003",

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AU - Schinstock, Carrie A.

AU - Gandhi, Manish J.

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N2 - Advances in posttransplant care, including new immunosuppressive medications have led to excellent short-term renal allograft survival. However, there is a small therapeutic window within which the patient and the clinician must balance the risk of rejection, with side effects such as infection, malignancy, and toxicity. Laboratory testing plays a key role in this ongoing monitoring, which includes relatively simple tests, such as serum creatinine, to complex tests, such as solid-phase assays, used to monitor for donor-specific antibody and surveillance allograft biopsies. This article reviews the role of the laboratory tests and surveillance biopsies in posttransplant monitoring.

AB - Advances in posttransplant care, including new immunosuppressive medications have led to excellent short-term renal allograft survival. However, there is a small therapeutic window within which the patient and the clinician must balance the risk of rejection, with side effects such as infection, malignancy, and toxicity. Laboratory testing plays a key role in this ongoing monitoring, which includes relatively simple tests, such as serum creatinine, to complex tests, such as solid-phase assays, used to monitor for donor-specific antibody and surveillance allograft biopsies. This article reviews the role of the laboratory tests and surveillance biopsies in posttransplant monitoring.

KW - De novo donor-specific antibodies

KW - Posttransplant GFR

KW - Posttransplant monitoring

KW - Posttransplant proteinuria

KW - Surveillance biopsy

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Maintaining the Health of the Renal Allograft: Laboratory and Histologic Monitoring After Kidney Transplantation

Abstract

Keywords

ASJC Scopus subject areas

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