Magnetic resonance spectroscopy, β-amyloid load, and cognition in a population-based sample of cognitively normal older adults

Kejal M Kantarci, Val Lowe, S. A. Przybelski, M. L. Senjem, S. D. Weigand, R. J. Ivnik, Rosebud O Roberts, Yonas Endale Geda, Bradley F Boeve, David S Knopman, Ronald Carl Petersen, Clifford R Jr. Jack

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Abstract

Objective: To determine the relationship between proton magnetic resonance spectroscopy (1H MRS) metabolites and β-amyloid (Aβ) load and the effects of Aβ load on the association between 1H MRS metabolites and cognitive function in cognitively normal older adults. Methods: We studied 311 cognitively normal older adults who participated in the populationbased Mayo Clinic Study of Aging from January 2009 through September 2010. Participants underwent 11C-Pittsburgh compound B (PiB) PET, 1H MRS from the posterior cingulate gyri, and neuropsychometric testing to assess memory, attention/executive, language, and visual-spatial domain functions within 6 months. Partial Spearman rank order correlations were adjusted for age, sex, and education. Results: Higher PiB retention was associated with abnormal elevations in myoinositol (mI)/creatine (Cr) (partial rs = 0.17; p = 0.003) and choline (Cho)/Cr (partial rs = 0.13; p = 0.022) ratios. Higher Cho/Cr was associated with worse performance on Auditory Verbal Learning Test Delayed Recall (partial rs = -0.12; p = 0.04), Trail Making Test Part B (partial rs = 0.12; p = 0.04), Wechsler Adult Intelligence Scale-Revised (WAIS-R) Digit Symbol (partial r s = -0.18; p < 0.01), and WAIS-R Block Design (partial r s=-0.12; p = 0.03). Associations between 1H MRS metabolites and cognitive function were not different among participants with high vs low PiB retention. Conclusion: In cognitively normal older adults, the 1H MRS metabolite ratios mI/Cr and Cho/Cr are associated with the preclinical pathologic processes in the Alzheimer disease cascade. Higher Cho/Cr is associated with worse performance on domain-specific cognitive tests independent of Aβ load, suggesting that Cho/Cr elevation may also be dependent on other preclinical dementia pathologies characterized by Cho/Cr elevation such as Lewy body or ischemic vascular disease in addition to Aβ load.

Original languageEnglish (US)
Pages (from-to)951-958
Number of pages8
JournalNeurology
Volume77
Issue number10
DOIs
StatePublished - Sep 6 2011

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Creatine
Amyloid
Cognition
Magnetic Resonance Spectroscopy
Choline
Population
Inositol
Intelligence
Trail Making Test
Lewy Bodies
Verbal Learning
Sex Education
Spectroscopy
Gyrus Cinguli
Pathologic Processes
Vascular Diseases
Dementia
Proton Magnetic Resonance Spectroscopy
Alzheimer Disease
Language

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

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Magnetic resonance spectroscopy, β-amyloid load, and cognition in a population-based sample of cognitively normal older adults. / Kantarci, Kejal M; Lowe, Val; Przybelski, S. A.; Senjem, M. L.; Weigand, S. D.; Ivnik, R. J.; Roberts, Rosebud O; Geda, Yonas Endale; Boeve, Bradley F; Knopman, David S; Petersen, Ronald Carl; Jack, Clifford R Jr.

In: Neurology, Vol. 77, No. 10, 06.09.2011, p. 951-958.

Research output: Contribution to journalArticle

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AU - Kantarci, Kejal M

AU - Lowe, Val

AU - Przybelski, S. A.

AU - Senjem, M. L.

AU - Weigand, S. D.

AU - Ivnik, R. J.

AU - Roberts, Rosebud O

AU - Geda, Yonas Endale

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AU - Knopman, David S

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AU - Jack, Clifford R Jr.

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