Magnetic resonance imaging of part-solid nodules a pilot study

Chi Wan Koo, Darin B. White, Ravi K. Lingineni, Tobias D Peikert, Kiaran Patrick McGee, Eric E. Sigmund, Victoria Tsang, Rickey E. Carter, Anne-Marie Gisele Sykes

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: The aim of the study was to assess whether magnetic resonance imaging (MRI) characteristics can distinguish benign from malignant part-solid pulmonary nodules and predict the aggressiveness of the latter. We also sought to compare MRI-derived parameters with morphologic and physiological values derived from conventional examinations such as computed tomography and positron emission tomography/computed tomography. Materials and Methods: This was an institutional review board- approved pilot study of 28 participants (23 women, mean age 73.5±13.8 y) with 32 biopsy-proven lesions. 3-T unenhanced pulmonary MRI examinations were performed with regions of interest drawn around lesions for T1, T2, T2∗, and diffusionweighted sequences. Apparent diffusion coefficient (ADC) and T2∗values were calculated. Two weeks later the regions of interest were redrawn. MRI parameters were compared with lesion pathology, maximal standard uptake value (SUVmax), and Hounsfield units (HU). MRI lesion visibility was correlated with solid component size and the percentage of solid component. Intraobserver and interobserver agreements were determined. Results: Only ADC values correlated with malignancy (P2/ms predicted malignancy with 83.3% sensitivity (area under the curve 0.79). ADC and T2∗correlated with adenocarcinoma subtypes (P0.11). SUVmax did not correlate with any MRI parameters (P>0.56). Visibility on T1-weighted images correlated with the percentage of solid components (P

Original languageEnglish (US)
Pages (from-to)2-10
Number of pages9
JournalJournal of Thoracic Imaging
Volume31
Issue number1
DOIs
StatePublished - 2016

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Magnetic Resonance Imaging
Lung
Research Ethics Committees
Area Under Curve
Neoplasms
Adenocarcinoma
Tomography
Pathology
Biopsy

Keywords

  • Apparent diffusion coefficient
  • Diffusion- weighted magnetic resonance imaging
  • Magnetic resonance imaging
  • Part-solid nodules

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pulmonary and Respiratory Medicine

Cite this

Magnetic resonance imaging of part-solid nodules a pilot study. / Koo, Chi Wan; White, Darin B.; Lingineni, Ravi K.; Peikert, Tobias D; McGee, Kiaran Patrick; Sigmund, Eric E.; Tsang, Victoria; Carter, Rickey E.; Sykes, Anne-Marie Gisele.

In: Journal of Thoracic Imaging, Vol. 31, No. 1, 2016, p. 2-10.

Research output: Contribution to journalArticle

Koo, Chi Wan ; White, Darin B. ; Lingineni, Ravi K. ; Peikert, Tobias D ; McGee, Kiaran Patrick ; Sigmund, Eric E. ; Tsang, Victoria ; Carter, Rickey E. ; Sykes, Anne-Marie Gisele. / Magnetic resonance imaging of part-solid nodules a pilot study. In: Journal of Thoracic Imaging. 2016 ; Vol. 31, No. 1. pp. 2-10.
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