Magnetic Resonance Imaging of Myocardial Contrast Enhancement with MS-325 and Its Relation to Myocardial Blood Flow and the Perfusion Reserve

Michael Jerosch-Herold, Xudong Hu, Naveen S Murthy, Carsten Rickers, Arthur E. Stillman

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Purpose: To determine with an intravascular contrast agent the relation between the rate of myocardial signal enhancement during the first pass (upslope) and myocardial blood flow (MBF), and to derive and validate a corrected perfusion reserve (PR) index from the upslope parameter. Materials and Methods: Measurements of the upslope parameter for myocardial contrast enhancement with an intravascular contrast agent (MS-325) were performed in a porcine model with ameroid coronary constrictor. MBF was estimated with MRI and was validated against separate invasive measurements with labeled microspheres. PR indices were calculated from the upslope of the tissue curves. A new PR index was corrected by the time delay between appearance of the tracer and the upslope maximum. Results: MBFs determined by MRI vs. MBFs measured with microspheres were in agreement within the 95% confidence intervals (CIs) for the identity relation. The new PR index slightly overestimated the MBF reserve by an average + 1.4% (95% CI = -44% to +46%). The uncorrected PR index underestimated the MBF reserve by -33% (95% CI = -92% to +25%). Conclusion: A perfusion index derived from the maximum upslope of myocardial contrast enhancement produces accurate estimates of the PR if corrected by the time-to-maximum upslope.

Original languageEnglish (US)
Pages (from-to)544-554
Number of pages11
JournalJournal of Magnetic Resonance Imaging
Volume18
Issue number5
DOIs
StatePublished - Nov 2003
Externally publishedYes

Fingerprint

Perfusion
Magnetic Resonance Imaging
Confidence Intervals
Microspheres
Contrast Media
gadofosveset trisodium
Swine

Keywords

  • Blood flow
  • Collateral flow
  • Contrast agent
  • Intravascular
  • Magnetic resonance
  • Myocardium
  • Perfusion reserve

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Magnetic Resonance Imaging of Myocardial Contrast Enhancement with MS-325 and Its Relation to Myocardial Blood Flow and the Perfusion Reserve. / Jerosch-Herold, Michael; Hu, Xudong; Murthy, Naveen S; Rickers, Carsten; Stillman, Arthur E.

In: Journal of Magnetic Resonance Imaging, Vol. 18, No. 5, 11.2003, p. 544-554.

Research output: Contribution to journalArticle

@article{d32833052d0a48d09ebeb70b8c4d9fb0,
title = "Magnetic Resonance Imaging of Myocardial Contrast Enhancement with MS-325 and Its Relation to Myocardial Blood Flow and the Perfusion Reserve",
abstract = "Purpose: To determine with an intravascular contrast agent the relation between the rate of myocardial signal enhancement during the first pass (upslope) and myocardial blood flow (MBF), and to derive and validate a corrected perfusion reserve (PR) index from the upslope parameter. Materials and Methods: Measurements of the upslope parameter for myocardial contrast enhancement with an intravascular contrast agent (MS-325) were performed in a porcine model with ameroid coronary constrictor. MBF was estimated with MRI and was validated against separate invasive measurements with labeled microspheres. PR indices were calculated from the upslope of the tissue curves. A new PR index was corrected by the time delay between appearance of the tracer and the upslope maximum. Results: MBFs determined by MRI vs. MBFs measured with microspheres were in agreement within the 95{\%} confidence intervals (CIs) for the identity relation. The new PR index slightly overestimated the MBF reserve by an average + 1.4{\%} (95{\%} CI = -44{\%} to +46{\%}). The uncorrected PR index underestimated the MBF reserve by -33{\%} (95{\%} CI = -92{\%} to +25{\%}). Conclusion: A perfusion index derived from the maximum upslope of myocardial contrast enhancement produces accurate estimates of the PR if corrected by the time-to-maximum upslope.",
keywords = "Blood flow, Collateral flow, Contrast agent, Intravascular, Magnetic resonance, Myocardium, Perfusion reserve",
author = "Michael Jerosch-Herold and Xudong Hu and Murthy, {Naveen S} and Carsten Rickers and Stillman, {Arthur E.}",
year = "2003",
month = "11",
doi = "10.1002/jmri.10384",
language = "English (US)",
volume = "18",
pages = "544--554",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Magnetic Resonance Imaging of Myocardial Contrast Enhancement with MS-325 and Its Relation to Myocardial Blood Flow and the Perfusion Reserve

AU - Jerosch-Herold, Michael

AU - Hu, Xudong

AU - Murthy, Naveen S

AU - Rickers, Carsten

AU - Stillman, Arthur E.

PY - 2003/11

Y1 - 2003/11

N2 - Purpose: To determine with an intravascular contrast agent the relation between the rate of myocardial signal enhancement during the first pass (upslope) and myocardial blood flow (MBF), and to derive and validate a corrected perfusion reserve (PR) index from the upslope parameter. Materials and Methods: Measurements of the upslope parameter for myocardial contrast enhancement with an intravascular contrast agent (MS-325) were performed in a porcine model with ameroid coronary constrictor. MBF was estimated with MRI and was validated against separate invasive measurements with labeled microspheres. PR indices were calculated from the upslope of the tissue curves. A new PR index was corrected by the time delay between appearance of the tracer and the upslope maximum. Results: MBFs determined by MRI vs. MBFs measured with microspheres were in agreement within the 95% confidence intervals (CIs) for the identity relation. The new PR index slightly overestimated the MBF reserve by an average + 1.4% (95% CI = -44% to +46%). The uncorrected PR index underestimated the MBF reserve by -33% (95% CI = -92% to +25%). Conclusion: A perfusion index derived from the maximum upslope of myocardial contrast enhancement produces accurate estimates of the PR if corrected by the time-to-maximum upslope.

AB - Purpose: To determine with an intravascular contrast agent the relation between the rate of myocardial signal enhancement during the first pass (upslope) and myocardial blood flow (MBF), and to derive and validate a corrected perfusion reserve (PR) index from the upslope parameter. Materials and Methods: Measurements of the upslope parameter for myocardial contrast enhancement with an intravascular contrast agent (MS-325) were performed in a porcine model with ameroid coronary constrictor. MBF was estimated with MRI and was validated against separate invasive measurements with labeled microspheres. PR indices were calculated from the upslope of the tissue curves. A new PR index was corrected by the time delay between appearance of the tracer and the upslope maximum. Results: MBFs determined by MRI vs. MBFs measured with microspheres were in agreement within the 95% confidence intervals (CIs) for the identity relation. The new PR index slightly overestimated the MBF reserve by an average + 1.4% (95% CI = -44% to +46%). The uncorrected PR index underestimated the MBF reserve by -33% (95% CI = -92% to +25%). Conclusion: A perfusion index derived from the maximum upslope of myocardial contrast enhancement produces accurate estimates of the PR if corrected by the time-to-maximum upslope.

KW - Blood flow

KW - Collateral flow

KW - Contrast agent

KW - Intravascular

KW - Magnetic resonance

KW - Myocardium

KW - Perfusion reserve

UR - http://www.scopus.com/inward/record.url?scp=0242331782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242331782&partnerID=8YFLogxK

U2 - 10.1002/jmri.10384

DO - 10.1002/jmri.10384

M3 - Article

VL - 18

SP - 544

EP - 554

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 5

ER -