Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease: the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort.

Kyongtae T. Bae, Fang Zhu, Arlene B. Chapman, Vicente Torres, Jared J. Grantham, Lisa M. Guay-Woodford, Deborah A. Baumgarten, Bernard Francis King, Louis H. Wetzel, Philip J. Kenney, Marijn E. Brummer, William M. Bennett, Saulo Klahr, Catherine M. Meyers, Xiaoling Zhang, Paul A. Thompson, J. Philip Miller

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Abstract

The objective of this study was to investigate the prevalence of hepatic cysts by age and gender in patients with early autosomal-dominant polycystic kidney disease (ADPKD) and to determine whether hepatic cyst volume is related to renal and renal cyst volumes by using magnetic resonance imaging (MRI). A total of 230 patients with ADPKD (94 men and 136 women) who were aged 15 to 46 yr and had relatively preserved renal function were studied. MRI images of the kidney and liver were obtained to measure renal, renal cyst, and hepatic cyst volumes. These volume measurements and hepatic cyst prevalence were compared in all patients and in subgroups on the basis of gender and age (15 to 24, 25 to 34, and 35 to 46 yr). The overall prevalence of hepatic cysts was 83%; the prevalence was 58, 85, and 94% in the sequential age groups and 85% in women and 79% in men. The prevalence was related directly to renal volume (chi2 = 4.30, P = 0.04) and to renal cyst volume (chi2 = 5.59, P = 0.02). The total hepatic cyst volume was significantly greater in women than in men (a logarithmic transformation mean of 5.27 versus 1.94 ml; P = 0.003). The average hepatic cyst volume was 0.25, 5.75, and 22.78 ml in sequential age groups. Hepatic cysts are evident in 94% of patients who are older than 35 yr and in 55% of individuals who are younger than 25 yr. Hepatic cysts are more prevalent and larger in total cyst volume in women than in men. Hepatic cyst prevalence and aggregate total hepatic cyst volume increased with age.

Original languageEnglish (US)
Pages (from-to)64-69
Number of pages6
JournalClinical journal of the American Society of Nephrology : CJASN
Volume1
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

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Autosomal Dominant Polycystic Kidney
Polycystic Kidney Diseases
Cysts
Magnetic Resonance Imaging
Liver
Kidney
Age Groups

ASJC Scopus subject areas

  • Medicine(all)

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Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease : the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort. / Bae, Kyongtae T.; Zhu, Fang; Chapman, Arlene B.; Torres, Vicente; Grantham, Jared J.; Guay-Woodford, Lisa M.; Baumgarten, Deborah A.; King, Bernard Francis; Wetzel, Louis H.; Kenney, Philip J.; Brummer, Marijn E.; Bennett, William M.; Klahr, Saulo; Meyers, Catherine M.; Zhang, Xiaoling; Thompson, Paul A.; Miller, J. Philip.

In: Clinical journal of the American Society of Nephrology : CJASN, Vol. 1, No. 1, 01.2006, p. 64-69.

Research output: Contribution to journalArticle

Bae, KT, Zhu, F, Chapman, AB, Torres, V, Grantham, JJ, Guay-Woodford, LM, Baumgarten, DA, King, BF, Wetzel, LH, Kenney, PJ, Brummer, ME, Bennett, WM, Klahr, S, Meyers, CM, Zhang, X, Thompson, PA & Miller, JP 2006, 'Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease: the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort.', Clinical journal of the American Society of Nephrology : CJASN, vol. 1, no. 1, pp. 64-69. https://doi.org/10.2215/CJN.00080605
Bae, Kyongtae T. ; Zhu, Fang ; Chapman, Arlene B. ; Torres, Vicente ; Grantham, Jared J. ; Guay-Woodford, Lisa M. ; Baumgarten, Deborah A. ; King, Bernard Francis ; Wetzel, Louis H. ; Kenney, Philip J. ; Brummer, Marijn E. ; Bennett, William M. ; Klahr, Saulo ; Meyers, Catherine M. ; Zhang, Xiaoling ; Thompson, Paul A. ; Miller, J. Philip. / Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease : the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort. In: Clinical journal of the American Society of Nephrology : CJASN. 2006 ; Vol. 1, No. 1. pp. 64-69.
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abstract = "The objective of this study was to investigate the prevalence of hepatic cysts by age and gender in patients with early autosomal-dominant polycystic kidney disease (ADPKD) and to determine whether hepatic cyst volume is related to renal and renal cyst volumes by using magnetic resonance imaging (MRI). A total of 230 patients with ADPKD (94 men and 136 women) who were aged 15 to 46 yr and had relatively preserved renal function were studied. MRI images of the kidney and liver were obtained to measure renal, renal cyst, and hepatic cyst volumes. These volume measurements and hepatic cyst prevalence were compared in all patients and in subgroups on the basis of gender and age (15 to 24, 25 to 34, and 35 to 46 yr). The overall prevalence of hepatic cysts was 83{\%}; the prevalence was 58, 85, and 94{\%} in the sequential age groups and 85{\%} in women and 79{\%} in men. The prevalence was related directly to renal volume (chi2 = 4.30, P = 0.04) and to renal cyst volume (chi2 = 5.59, P = 0.02). The total hepatic cyst volume was significantly greater in women than in men (a logarithmic transformation mean of 5.27 versus 1.94 ml; P = 0.003). The average hepatic cyst volume was 0.25, 5.75, and 22.78 ml in sequential age groups. Hepatic cysts are evident in 94{\%} of patients who are older than 35 yr and in 55{\%} of individuals who are younger than 25 yr. Hepatic cysts are more prevalent and larger in total cyst volume in women than in men. Hepatic cyst prevalence and aggregate total hepatic cyst volume increased with age.",
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AU - Torres, Vicente

AU - Grantham, Jared J.

AU - Guay-Woodford, Lisa M.

AU - Baumgarten, Deborah A.

AU - King, Bernard Francis

AU - Wetzel, Louis H.

AU - Kenney, Philip J.

AU - Brummer, Marijn E.

AU - Bennett, William M.

AU - Klahr, Saulo

AU - Meyers, Catherine M.

AU - Zhang, Xiaoling

AU - Thompson, Paul A.

AU - Miller, J. Philip

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N2 - The objective of this study was to investigate the prevalence of hepatic cysts by age and gender in patients with early autosomal-dominant polycystic kidney disease (ADPKD) and to determine whether hepatic cyst volume is related to renal and renal cyst volumes by using magnetic resonance imaging (MRI). A total of 230 patients with ADPKD (94 men and 136 women) who were aged 15 to 46 yr and had relatively preserved renal function were studied. MRI images of the kidney and liver were obtained to measure renal, renal cyst, and hepatic cyst volumes. These volume measurements and hepatic cyst prevalence were compared in all patients and in subgroups on the basis of gender and age (15 to 24, 25 to 34, and 35 to 46 yr). The overall prevalence of hepatic cysts was 83%; the prevalence was 58, 85, and 94% in the sequential age groups and 85% in women and 79% in men. The prevalence was related directly to renal volume (chi2 = 4.30, P = 0.04) and to renal cyst volume (chi2 = 5.59, P = 0.02). The total hepatic cyst volume was significantly greater in women than in men (a logarithmic transformation mean of 5.27 versus 1.94 ml; P = 0.003). The average hepatic cyst volume was 0.25, 5.75, and 22.78 ml in sequential age groups. Hepatic cysts are evident in 94% of patients who are older than 35 yr and in 55% of individuals who are younger than 25 yr. Hepatic cysts are more prevalent and larger in total cyst volume in women than in men. Hepatic cyst prevalence and aggregate total hepatic cyst volume increased with age.

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