TY - JOUR
T1 - Magnetic resonance elastography of liver in healthy asians
T2 - Normal liver stiffness quantification and reproducibility assessment
AU - Venkatesh, Sudhakar K.
AU - Wang, Gang
AU - Teo, Lynette L.S.
AU - Ang, Bertrand W.L.
PY - 2014/1
Y1 - 2014/1
N2 - Purpose To determine normal liver stiffness values evaluated with magnetic resonance elastography (MRE) in healthy normal Asian volunteers and assess its reproducibility. Materials and Methods Liver stiffness was evaluated with MRE in 41 healthy Asians (23 females, 18 males; mean age, 41.8 years, and mean body mass index [BMI], 23.4 kg/m2) on a 1.5T clinical scanner. The correlations between mean liver stiffness and age, gender, BMI, and fat fraction percentage of the liver were studied. Another 12 volunteers underwent liver MRE exams on two separate days 4-6 weeks apart under similar conditions for reproducibility assessment. Intraclass correlation coefficient (ICC) analysis was performed and within-subject coefficient of variation (CV) of stiffness was estimated. Results The mean ± standard deviation (SD) of liver stiffness in normal healthy Asian subjects was 2.09 ± 0.22 kPa (95% confidence interval [CI], 2.04-2.15 kPa; range 1.68-2.48 kPa). The mean liver stiffness did not significantly correlate with age, gender, BMI, or fat content of the liver. The ICC for mean liver stiffness was 0.90 (95% CI, 0.78-0.96) and CV ranged from 2.2%-11.4%. Conclusion The liver stiffness in normal Asians is not affected by age, gender, BMI, or fat content. Liver stiffness with MRE is highly reproducible. J. Magn. Reson. Imaging 2014;39:1-8. © 2013 Wiley Periodicals, Inc.
AB - Purpose To determine normal liver stiffness values evaluated with magnetic resonance elastography (MRE) in healthy normal Asian volunteers and assess its reproducibility. Materials and Methods Liver stiffness was evaluated with MRE in 41 healthy Asians (23 females, 18 males; mean age, 41.8 years, and mean body mass index [BMI], 23.4 kg/m2) on a 1.5T clinical scanner. The correlations between mean liver stiffness and age, gender, BMI, and fat fraction percentage of the liver were studied. Another 12 volunteers underwent liver MRE exams on two separate days 4-6 weeks apart under similar conditions for reproducibility assessment. Intraclass correlation coefficient (ICC) analysis was performed and within-subject coefficient of variation (CV) of stiffness was estimated. Results The mean ± standard deviation (SD) of liver stiffness in normal healthy Asian subjects was 2.09 ± 0.22 kPa (95% confidence interval [CI], 2.04-2.15 kPa; range 1.68-2.48 kPa). The mean liver stiffness did not significantly correlate with age, gender, BMI, or fat content of the liver. The ICC for mean liver stiffness was 0.90 (95% CI, 0.78-0.96) and CV ranged from 2.2%-11.4%. Conclusion The liver stiffness in normal Asians is not affected by age, gender, BMI, or fat content. Liver stiffness with MRE is highly reproducible. J. Magn. Reson. Imaging 2014;39:1-8. © 2013 Wiley Periodicals, Inc.
KW - age
KW - gender
KW - liver stiffness measurement
KW - magnetic resonance elastography
KW - normal healthy subjects
KW - reproducibility
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U2 - 10.1002/jmri.24084
DO - 10.1002/jmri.24084
M3 - Article
C2 - 24123300
AN - SCOPUS:84890551032
SN - 1053-1807
VL - 39
SP - 1
EP - 8
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 1
ER -