Magnetic resonance elastography of frontotemporal dementia

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Purpose To investigate the feasibility of utilizing brain stiffness as a potential biomarker for behavioral variant frontotemporal dementia (bvFTD) patients. Magnetic resonance elastography (MRE) is a noninvasive technique for evaluating the mechanical properties of brain tissue in vivo. MRE has demonstrated decreased brain stiffness in patients with Alzheimer's disease. Materials and Methods We examined five male subjects with bvFTD and nine cognitively normal age-matched male controls (NC) with brain 3T MRE. Stiffness was calculated in nine regions of interest (ROIs): whole brain (entire cerebrum excluding cerebellum), frontal lobes, occipital lobes, parietal lobes, temporal lobes, deep gray matter / white matter (GM/WM; insula, deep gray nuclei and white matter tracts), cerebellum, sensorimotor cortex (pre- and postcentral gyri), and a composite region labeled FT (frontal and temporal lobes excluding the pre- and postcentral gyri). Results Significantly lower stiffness values were observed in the whole brain (P = 0.007), frontal lobe (P = 0.001), and temporal lobes (P = 0.005) of bvFTD patients compared to NC. No significant stiffness differences were observed in any other ROIs of bvFTD patients compared to NC (P > 0.05). These results demonstrate that statistically significant brain softening occurs in the frontal and temporal lobes of bvFTD patients, which corresponds to the expected pathophysiology of bvFTD. Conclusion Future studies evaluating the feasibility of brain MRE for early disease detection and monitoring disease progression could shed new insights into understanding the mechanisms involved in bvFTD. J. Magn. Reson. Imaging 2016;43:474-478.

Original languageEnglish (US)
Pages (from-to)474-478
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Volume43
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Elasticity Imaging Techniques
Frontotemporal Dementia
Brain
Frontal Lobe
Temporal Lobe
Somatosensory Cortex
Cerebellum
Occipital Lobe
Parietal Lobe
Cerebrum
Feasibility Studies
Disease Progression
Early Diagnosis
Alzheimer Disease
Biomarkers

Keywords

  • behavioral variant frontotemporal dementia (bvFTD)
  • brain stiffness
  • frontotemporal dementia (FTD)
  • magnetic resonance elastography (MRE)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{f45801f52a4e4e4b85dc9eb75f6ba151,
title = "Magnetic resonance elastography of frontotemporal dementia",
abstract = "Purpose To investigate the feasibility of utilizing brain stiffness as a potential biomarker for behavioral variant frontotemporal dementia (bvFTD) patients. Magnetic resonance elastography (MRE) is a noninvasive technique for evaluating the mechanical properties of brain tissue in vivo. MRE has demonstrated decreased brain stiffness in patients with Alzheimer's disease. Materials and Methods We examined five male subjects with bvFTD and nine cognitively normal age-matched male controls (NC) with brain 3T MRE. Stiffness was calculated in nine regions of interest (ROIs): whole brain (entire cerebrum excluding cerebellum), frontal lobes, occipital lobes, parietal lobes, temporal lobes, deep gray matter / white matter (GM/WM; insula, deep gray nuclei and white matter tracts), cerebellum, sensorimotor cortex (pre- and postcentral gyri), and a composite region labeled FT (frontal and temporal lobes excluding the pre- and postcentral gyri). Results Significantly lower stiffness values were observed in the whole brain (P = 0.007), frontal lobe (P = 0.001), and temporal lobes (P = 0.005) of bvFTD patients compared to NC. No significant stiffness differences were observed in any other ROIs of bvFTD patients compared to NC (P > 0.05). These results demonstrate that statistically significant brain softening occurs in the frontal and temporal lobes of bvFTD patients, which corresponds to the expected pathophysiology of bvFTD. Conclusion Future studies evaluating the feasibility of brain MRE for early disease detection and monitoring disease progression could shed new insights into understanding the mechanisms involved in bvFTD. J. Magn. Reson. Imaging 2016;43:474-478.",
keywords = "behavioral variant frontotemporal dementia (bvFTD), brain stiffness, frontotemporal dementia (FTD), magnetic resonance elastography (MRE)",
author = "John Huston and Matthew Murphy and Boeve, {Bradley F} and Nikoo Fattahi and Arvin Forghanian-Arani and Glaser, {Kevin J.} and Armando Manduca and Jones, {David T} and Ehman, {Richard Lorne}",
year = "2016",
month = "2",
day = "1",
doi = "10.1002/jmri.24977",
language = "English (US)",
volume = "43",
pages = "474--478",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Magnetic resonance elastography of frontotemporal dementia

AU - Huston, John

AU - Murphy, Matthew

AU - Boeve, Bradley F

AU - Fattahi, Nikoo

AU - Forghanian-Arani, Arvin

AU - Glaser, Kevin J.

AU - Manduca, Armando

AU - Jones, David T

AU - Ehman, Richard Lorne

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Purpose To investigate the feasibility of utilizing brain stiffness as a potential biomarker for behavioral variant frontotemporal dementia (bvFTD) patients. Magnetic resonance elastography (MRE) is a noninvasive technique for evaluating the mechanical properties of brain tissue in vivo. MRE has demonstrated decreased brain stiffness in patients with Alzheimer's disease. Materials and Methods We examined five male subjects with bvFTD and nine cognitively normal age-matched male controls (NC) with brain 3T MRE. Stiffness was calculated in nine regions of interest (ROIs): whole brain (entire cerebrum excluding cerebellum), frontal lobes, occipital lobes, parietal lobes, temporal lobes, deep gray matter / white matter (GM/WM; insula, deep gray nuclei and white matter tracts), cerebellum, sensorimotor cortex (pre- and postcentral gyri), and a composite region labeled FT (frontal and temporal lobes excluding the pre- and postcentral gyri). Results Significantly lower stiffness values were observed in the whole brain (P = 0.007), frontal lobe (P = 0.001), and temporal lobes (P = 0.005) of bvFTD patients compared to NC. No significant stiffness differences were observed in any other ROIs of bvFTD patients compared to NC (P > 0.05). These results demonstrate that statistically significant brain softening occurs in the frontal and temporal lobes of bvFTD patients, which corresponds to the expected pathophysiology of bvFTD. Conclusion Future studies evaluating the feasibility of brain MRE for early disease detection and monitoring disease progression could shed new insights into understanding the mechanisms involved in bvFTD. J. Magn. Reson. Imaging 2016;43:474-478.

AB - Purpose To investigate the feasibility of utilizing brain stiffness as a potential biomarker for behavioral variant frontotemporal dementia (bvFTD) patients. Magnetic resonance elastography (MRE) is a noninvasive technique for evaluating the mechanical properties of brain tissue in vivo. MRE has demonstrated decreased brain stiffness in patients with Alzheimer's disease. Materials and Methods We examined five male subjects with bvFTD and nine cognitively normal age-matched male controls (NC) with brain 3T MRE. Stiffness was calculated in nine regions of interest (ROIs): whole brain (entire cerebrum excluding cerebellum), frontal lobes, occipital lobes, parietal lobes, temporal lobes, deep gray matter / white matter (GM/WM; insula, deep gray nuclei and white matter tracts), cerebellum, sensorimotor cortex (pre- and postcentral gyri), and a composite region labeled FT (frontal and temporal lobes excluding the pre- and postcentral gyri). Results Significantly lower stiffness values were observed in the whole brain (P = 0.007), frontal lobe (P = 0.001), and temporal lobes (P = 0.005) of bvFTD patients compared to NC. No significant stiffness differences were observed in any other ROIs of bvFTD patients compared to NC (P > 0.05). These results demonstrate that statistically significant brain softening occurs in the frontal and temporal lobes of bvFTD patients, which corresponds to the expected pathophysiology of bvFTD. Conclusion Future studies evaluating the feasibility of brain MRE for early disease detection and monitoring disease progression could shed new insights into understanding the mechanisms involved in bvFTD. J. Magn. Reson. Imaging 2016;43:474-478.

KW - behavioral variant frontotemporal dementia (bvFTD)

KW - brain stiffness

KW - frontotemporal dementia (FTD)

KW - magnetic resonance elastography (MRE)

UR - http://www.scopus.com/inward/record.url?scp=84959457189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959457189&partnerID=8YFLogxK

U2 - 10.1002/jmri.24977

DO - 10.1002/jmri.24977

M3 - Article

C2 - 26130216

AN - SCOPUS:84959457189

VL - 43

SP - 474

EP - 478

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 2

ER -