Magnetic resonance diagnosis of congenital hypopituitarism in children with optic nerve hypoplasia

Paul H. Phillips, Christine Spear, Michael C. Brodsky

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Purpose: To determine whether structural abnormalities of the neurohypophysis, as detected by magnetic resonance imaging (MRI), can be used to diagnose hypopituitarism in children with optic nerve hypoplasia. Methods: Retrospective analysis of 67 children with optic nerve hypoplasia who had MRI and pediatric endocrinologic evaluation at Arkansas Children's Hospital from 1989 to 1999. Results: A total of 26 children with optic nerve hypoplasia had pituitary hormone deficiency. MRI disclosed posterior pituitary ectopia in 16 of these cases, absence of the pituitary infundibulum and posterior pituitary bright spot in 7 of these cases, and a normal neurohypophysis in 3 of these cases. All 41 children with optic nerve hypoplasia and normal endocrinologic function had a normal neurohypophysis. Conclusion: MRI of the neurohypophysis can predict when congenital hypopituitarism will be associated with optic nerve hypoplasia.

Original languageEnglish (US)
Pages (from-to)275-280
Number of pages6
JournalJournal of AAPOS
Volume5
Issue number5
DOIs
StatePublished - Oct 2001

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Ophthalmology

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