Magnetic resonance diagnosis of congenital hypopituitarism in children with optic nerve hypoplasia

Paul H. Phillips; Christine Spear; Michael C. Brodsky

doi:10.1067/mpa.2001.118220

Magnetic resonance diagnosis of congenital hypopituitarism in children with optic nerve hypoplasia

Paul H. Phillips, Christine Spear, Michael C. Brodsky

Ophthalmology

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Purpose: To determine whether structural abnormalities of the neurohypophysis, as detected by magnetic resonance imaging (MRI), can be used to diagnose hypopituitarism in children with optic nerve hypoplasia. Methods: Retrospective analysis of 67 children with optic nerve hypoplasia who had MRI and pediatric endocrinologic evaluation at Arkansas Children's Hospital from 1989 to 1999. Results: A total of 26 children with optic nerve hypoplasia had pituitary hormone deficiency. MRI disclosed posterior pituitary ectopia in 16 of these cases, absence of the pituitary infundibulum and posterior pituitary bright spot in 7 of these cases, and a normal neurohypophysis in 3 of these cases. All 41 children with optic nerve hypoplasia and normal endocrinologic function had a normal neurohypophysis. Conclusion: MRI of the neurohypophysis can predict when congenital hypopituitarism will be associated with optic nerve hypoplasia.

Original language	English (US)
Pages (from-to)	275-280
Number of pages	6
Journal	Journal of AAPOS
Volume	5
Issue number	5
DOIs	https://doi.org/10.1067/mpa.2001.118220
State	Published - Oct 2001

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Ophthalmology

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10.1067/mpa.2001.118220

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title = "Magnetic resonance diagnosis of congenital hypopituitarism in children with optic nerve hypoplasia",

abstract = "Purpose: To determine whether structural abnormalities of the neurohypophysis, as detected by magnetic resonance imaging (MRI), can be used to diagnose hypopituitarism in children with optic nerve hypoplasia. Methods: Retrospective analysis of 67 children with optic nerve hypoplasia who had MRI and pediatric endocrinologic evaluation at Arkansas Children's Hospital from 1989 to 1999. Results: A total of 26 children with optic nerve hypoplasia had pituitary hormone deficiency. MRI disclosed posterior pituitary ectopia in 16 of these cases, absence of the pituitary infundibulum and posterior pituitary bright spot in 7 of these cases, and a normal neurohypophysis in 3 of these cases. All 41 children with optic nerve hypoplasia and normal endocrinologic function had a normal neurohypophysis. Conclusion: MRI of the neurohypophysis can predict when congenital hypopituitarism will be associated with optic nerve hypoplasia.",

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AU - Spear, Christine

AU - Brodsky, Michael C.

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N2 - Purpose: To determine whether structural abnormalities of the neurohypophysis, as detected by magnetic resonance imaging (MRI), can be used to diagnose hypopituitarism in children with optic nerve hypoplasia. Methods: Retrospective analysis of 67 children with optic nerve hypoplasia who had MRI and pediatric endocrinologic evaluation at Arkansas Children's Hospital from 1989 to 1999. Results: A total of 26 children with optic nerve hypoplasia had pituitary hormone deficiency. MRI disclosed posterior pituitary ectopia in 16 of these cases, absence of the pituitary infundibulum and posterior pituitary bright spot in 7 of these cases, and a normal neurohypophysis in 3 of these cases. All 41 children with optic nerve hypoplasia and normal endocrinologic function had a normal neurohypophysis. Conclusion: MRI of the neurohypophysis can predict when congenital hypopituitarism will be associated with optic nerve hypoplasia.

AB - Purpose: To determine whether structural abnormalities of the neurohypophysis, as detected by magnetic resonance imaging (MRI), can be used to diagnose hypopituitarism in children with optic nerve hypoplasia. Methods: Retrospective analysis of 67 children with optic nerve hypoplasia who had MRI and pediatric endocrinologic evaluation at Arkansas Children's Hospital from 1989 to 1999. Results: A total of 26 children with optic nerve hypoplasia had pituitary hormone deficiency. MRI disclosed posterior pituitary ectopia in 16 of these cases, absence of the pituitary infundibulum and posterior pituitary bright spot in 7 of these cases, and a normal neurohypophysis in 3 of these cases. All 41 children with optic nerve hypoplasia and normal endocrinologic function had a normal neurohypophysis. Conclusion: MRI of the neurohypophysis can predict when congenital hypopituitarism will be associated with optic nerve hypoplasia.

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Magnetic resonance diagnosis of congenital hypopituitarism in children with optic nerve hypoplasia

Abstract

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