Lysosomes in cell death

Maria Eugenia Guicciardi, Marcel Leist, Gregory James Gores

Research output: Contribution to journalArticle

517 Citations (Scopus)

Abstract

For many years apoptosis research has focused on caspases and their putative role as sole executioners of programmed cell death. Accumulating information now suggests that lysosomal cathepsins are also pivotally involved in this process, especially in pathological conditions. In particular, the role of lysosomes and lysosomal enzymes in initiation and execution of the apoptotic program has become clear in several models, to the point that the existence of a 'lysosomal pathway of apoptosis' is now generally accepted. This pathway of apoptosis can be activated by death receptors, lipid mediators, and photo-damage. Lysosomal proteases can be released from the lysosomes into the cytosol, where they contribute to the apoptotic cascade upstream of mitochondria. This review focuses on the players and the molecular mechanisms involved in the lysosomal pathway of apoptosis as well as on the importance of this pathway in development and pathology.

Original languageEnglish (US)
Pages (from-to)2881-2890
Number of pages10
JournalOncogene
Volume23
Issue number16 REV. ISS. 2
DOIs
StatePublished - Apr 12 2004

Fingerprint

Lysosomes
Cell Death
Apoptosis
Cathepsins
Death Domain Receptors
Caspases
Cytosol
Mitochondria
Peptide Hydrolases
Pathology
Lipids
Enzymes
Research

Keywords

  • Cathepsins
  • Spi2A
  • TNFα

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Guicciardi, M. E., Leist, M., & Gores, G. J. (2004). Lysosomes in cell death. Oncogene, 23(16 REV. ISS. 2), 2881-2890. https://doi.org/10.1038/sj.onc.1207512

Lysosomes in cell death. / Guicciardi, Maria Eugenia; Leist, Marcel; Gores, Gregory James.

In: Oncogene, Vol. 23, No. 16 REV. ISS. 2, 12.04.2004, p. 2881-2890.

Research output: Contribution to journalArticle

Guicciardi, ME, Leist, M & Gores, GJ 2004, 'Lysosomes in cell death', Oncogene, vol. 23, no. 16 REV. ISS. 2, pp. 2881-2890. https://doi.org/10.1038/sj.onc.1207512
Guicciardi ME, Leist M, Gores GJ. Lysosomes in cell death. Oncogene. 2004 Apr 12;23(16 REV. ISS. 2):2881-2890. https://doi.org/10.1038/sj.onc.1207512
Guicciardi, Maria Eugenia ; Leist, Marcel ; Gores, Gregory James. / Lysosomes in cell death. In: Oncogene. 2004 ; Vol. 23, No. 16 REV. ISS. 2. pp. 2881-2890.
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