Lymphoepithelioma-like carcinoma of the lung: Radiologic features of an uncommon primary pulmonary neoplasm

Joseph M. Hoxworth, Douglas K. Hanks, Philip A Araoz, Brett M. Elicker, Gautham P. Reddy, W. Richard Webb, Jessica W T Leung, Michael Gotway

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

OBJECTIVE. The purpose of this study was to review the chest radiographic, CT, and MRI appearances of primary pulmonary lymphoepithelioma-like carcinoma (LELC). CONCLUSION. Primary pulmonary LELC is histopathologically identical to nasopharyngeal carcinoma. The radiographic, CT, and MRI features of primary pulmonary LELC are nonspecific, often resembling those of bronchogenic carcinoma. Primary pulmonary LELC usually presents as a poorly circumscribed, enhancing, peripheral solitary pulmonary nodule on CT; necrosis may be present and is considered a poor prognostic sign. MRI shows isointense to low-intensity signal on T1-weighted images and mildly increased signal on T2-weighted images; enhancement of abnormal tissue is typical. Most patients present with early-stage disease. Primary pulmonary LELC should be suspected in selected patients and requires differentiation from bronchogenic carcinoma and metastatic nasopharyngeal carcinoma.

Original languageEnglish (US)
Pages (from-to)1294-1299
Number of pages6
JournalAmerican Journal of Roentgenology
Volume186
Issue number5
DOIs
StatePublished - May 2006

Fingerprint

Lung Neoplasms
Carcinoma
Lung
Bronchogenic Carcinoma
Solitary Pulmonary Nodule
Necrosis
Thorax
Nasopharyngeal carcinoma

Keywords

  • Biopsy
  • CT
  • Epstein-barr virus
  • Lung cancer
  • MRI
  • Primary pulmonary lymphoepithelioma-like carcinoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Lymphoepithelioma-like carcinoma of the lung : Radiologic features of an uncommon primary pulmonary neoplasm. / Hoxworth, Joseph M.; Hanks, Douglas K.; Araoz, Philip A; Elicker, Brett M.; Reddy, Gautham P.; Webb, W. Richard; Leung, Jessica W T; Gotway, Michael.

In: American Journal of Roentgenology, Vol. 186, No. 5, 05.2006, p. 1294-1299.

Research output: Contribution to journalArticle

Hoxworth, Joseph M. ; Hanks, Douglas K. ; Araoz, Philip A ; Elicker, Brett M. ; Reddy, Gautham P. ; Webb, W. Richard ; Leung, Jessica W T ; Gotway, Michael. / Lymphoepithelioma-like carcinoma of the lung : Radiologic features of an uncommon primary pulmonary neoplasm. In: American Journal of Roentgenology. 2006 ; Vol. 186, No. 5. pp. 1294-1299.
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