Lymphocytic choriomeningitis infection of the central nervous system

Sylvia Kang, Dorian B. McGavern

Research output: Contribution to journalReview article

49 Citations (Scopus)

Abstract

Viral infection of the central nervous system (CNS) can result in a multitude of responses including pathology, persistence or immune clearance. Lymphocytic choriomeningitis virus (LCMV) is a powerful model system to explore these potential outcomes of CNS infection due to the diversity of responses that can be achieved after viral inoculation. Several factors including tropism, timing, dose and variant of LCMV in combination with the development or suppression of the corresponding immune response dictates whether lethal meningitis, chronic infection or clearance of LCMV in the CNS will occur. Importantly, the functionality and positioning of the LCMV-specific CD8 + T cell response are critical in directing the subsequent outcome of CNS LCMV infection. Although a basic understanding of LCMV and immune interactions in the brain exists, the molecular machinery that shapes the balance between pathogenesis and clearance in the LCMV-infected CNS remains to be elucidated. This review covers the various outcomes of LCMV infection in the CNS and what is currently known about the impact of the virus itself versus the immune response in the development of disease or clearance.

Original languageEnglish (US)
Pages (from-to)4529-4543
Number of pages15
JournalFrontiers in Bioscience
Volume13
Issue number12
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Lymphocytic Choriomeningitis
Lymphocytic choriomeningitis virus
Central Nervous System Infections
Neurology
Viruses
Central Nervous System
Virus Diseases
Central Nervous System Viral Diseases
Tropism
T-cells
Meningitis
Pathology
Machinery
Brain
T-Lymphocytes

Keywords

  • Astrocytes
  • Behavior
  • Brain
  • Clone 13
  • Growth hormone
  • Immunodeficient
  • Immunotherapy
  • LCMV
  • Meningitis
  • Neonates
  • Neurons
  • Review
  • T cell
  • Virus

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lymphocytic choriomeningitis infection of the central nervous system. / Kang, Sylvia; McGavern, Dorian B.

In: Frontiers in Bioscience, Vol. 13, No. 12, 2008, p. 4529-4543.

Research output: Contribution to journalReview article

Kang, Sylvia ; McGavern, Dorian B. / Lymphocytic choriomeningitis infection of the central nervous system. In: Frontiers in Bioscience. 2008 ; Vol. 13, No. 12. pp. 4529-4543.
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