Lung tissue-resident memory T cells: the gatekeeper to respiratory viral (re)-infection

Jinyi Tang, Jie Sun

Research output: Contribution to journalReview articlepeer-review


The discovery of lung tissue-resident memory T (TRM) cells and the elucidation of their function in antiviral immunity have inspired considerable efforts to leverage the power of TRM cells, in defense to the infections and reinfections by respiratory viruses. Here, we have reviewed lung TRM cell identification, molecular regulation, and function after influenza and SARS-CoV-2 infections. Furthermore, we have discussed emerging data on TRM responses induced by systemic and mucosal vaccination strategies. We hope that our current outstanding of TRM cells in this review could provide insights toward the development of vaccines capable of inducing highly efficacious mucosal TRM responses for protection against respiratory viral infections.

Original languageEnglish (US)
Article number102278
JournalCurrent Opinion in Immunology
StatePublished - Feb 2023

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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