TY - JOUR
T1 - Lung tissue-resident memory T cells
T2 - the gatekeeper to respiratory viral (re)-infection
AU - Tang, Jinyi
AU - Sun, Jie
N1 - Funding Information:
We thank Yue Wu and Harish Narasimhan for critical reading of this paper. This work was supported by the National Institutes of Health, USA ( AI147394 , AI154598 , AI112844 , and AG069264 to J.S.).
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2023/2
Y1 - 2023/2
N2 - The discovery of lung tissue-resident memory T (TRM) cells and the elucidation of their function in antiviral immunity have inspired considerable efforts to leverage the power of TRM cells, in defense to the infections and reinfections by respiratory viruses. Here, we have reviewed lung TRM cell identification, molecular regulation, and function after influenza and SARS-CoV-2 infections. Furthermore, we have discussed emerging data on TRM responses induced by systemic and mucosal vaccination strategies. We hope that our current outstanding of TRM cells in this review could provide insights toward the development of vaccines capable of inducing highly efficacious mucosal TRM responses for protection against respiratory viral infections.
AB - The discovery of lung tissue-resident memory T (TRM) cells and the elucidation of their function in antiviral immunity have inspired considerable efforts to leverage the power of TRM cells, in defense to the infections and reinfections by respiratory viruses. Here, we have reviewed lung TRM cell identification, molecular regulation, and function after influenza and SARS-CoV-2 infections. Furthermore, we have discussed emerging data on TRM responses induced by systemic and mucosal vaccination strategies. We hope that our current outstanding of TRM cells in this review could provide insights toward the development of vaccines capable of inducing highly efficacious mucosal TRM responses for protection against respiratory viral infections.
UR - http://www.scopus.com/inward/record.url?scp=85144533844&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85144533844&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2022.102278
DO - 10.1016/j.coi.2022.102278
M3 - Review article
C2 - 36565508
AN - SCOPUS:85144533844
SN - 0952-7915
VL - 80
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
M1 - 102278
ER -