Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain

María C. González-Fernández, Elena Lezcano, Owen A. Ross, Juan C. Gómez-Esteban, Fernando Gómez-Busto, Fernando Velasco, Maite Alvarez-Alvarez, María B. Rodríguez-Martínez, Roberto Ciordia, Juan J. Zarranz, Matthew J. Farrer, Ignacio F. Mata, Marian M. de Pancorbo

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Herein we describe a comparative clinical and genetic study of Lrrk2-associated parkinsonism in Northern Spain. In our sample from the Basque region, Lrrk2 R1441G and G2019S account for 15 out of 50 kindreds (30%) with familial Parkinson's disease. We observe common founder haplotypes for both R1441G and G2019S carriers. Our findings highlight the importance of Lrrk2 parkinsonism in this population and may have important consequences for its extended Diaspora in North, Central and South Americas.

Original languageEnglish (US)
Pages (from-to)509-515
Number of pages7
JournalParkinsonism and Related Disorders
Volume13
Issue number8
DOIs
StatePublished - Dec 1 2007

Keywords

  • Dardarina
  • LRRK2
  • Mutation
  • Parkinson's disease
  • Spain

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain'. Together they form a unique fingerprint.

  • Cite this

    González-Fernández, M. C., Lezcano, E., Ross, O. A., Gómez-Esteban, J. C., Gómez-Busto, F., Velasco, F., Alvarez-Alvarez, M., Rodríguez-Martínez, M. B., Ciordia, R., Zarranz, J. J., Farrer, M. J., Mata, I. F., & de Pancorbo, M. M. (2007). Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain. Parkinsonism and Related Disorders, 13(8), 509-515. https://doi.org/10.1016/j.parkreldis.2007.04.003