Lower gastrointestinal tract cancer predisposition syndromes

Neel B. Shah, Noralane Morey Lindor

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Although inherited predisposition to colorectal cancer (CRC) has been suspected for more than 100 years, definitive proof of Mendelian syndromes had to await maturation of molecular genetic technologies. Since the l980s, the genetics of several clinically distinct entities has been revealed. Five disorders that share a hereditary predisposition to CRC are reviewed in this article.

Original languageEnglish (US)
Pages (from-to)1229-1252
Number of pages24
JournalHematology/Oncology Clinics of North America
Volume24
Issue number6
DOIs
StatePublished - Dec 2010

Fingerprint

Lower Gastrointestinal Tract
Gastrointestinal Neoplasms
Colorectal Neoplasms
Molecular Biology
Technology

Keywords

  • Cancer
  • Colorectal
  • Genetic syndrome
  • Lower GI
  • Risk

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Lower gastrointestinal tract cancer predisposition syndromes. / Shah, Neel B.; Lindor, Noralane Morey.

In: Hematology/Oncology Clinics of North America, Vol. 24, No. 6, 12.2010, p. 1229-1252.

Research output: Contribution to journalArticle

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