Lower gastrointestinal tract cancer predisposition syndromes

Neel B. Shah; Noralane M. Lindor

doi:10.1016/j.hoc.2010.08.012

Lower gastrointestinal tract cancer predisposition syndromes

Neel B. Shah, Noralane M. Lindor

Research

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Although inherited predisposition to colorectal cancer (CRC) has been suspected for more than 100 years, definitive proof of Mendelian syndromes had to await maturation of molecular genetic technologies. Since the l980s, the genetics of several clinically distinct entities has been revealed. Five disorders that share a hereditary predisposition to CRC are reviewed in this article.

Original language	English (US)
Pages (from-to)	1229-1252
Number of pages	24
Journal	Hematology/Oncology Clinics of North America
Volume	24
Issue number	6
DOIs	https://doi.org/10.1016/j.hoc.2010.08.012
State	Published - Dec 2010

Keywords

Cancer
Colorectal
Genetic syndrome
Lower GI
Risk

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.hoc.2010.08.012

Cite this

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title = "Lower gastrointestinal tract cancer predisposition syndromes",

abstract = "Although inherited predisposition to colorectal cancer (CRC) has been suspected for more than 100 years, definitive proof of Mendelian syndromes had to await maturation of molecular genetic technologies. Since the l980s, the genetics of several clinically distinct entities has been revealed. Five disorders that share a hereditary predisposition to CRC are reviewed in this article.",

keywords = "Cancer, Colorectal, Genetic syndrome, Lower GI, Risk",

author = "Shah, {Neel B.} and Lindor, {Noralane M.}",

year = "2010",

month = dec,

doi = "10.1016/j.hoc.2010.08.012",

language = "English (US)",

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T1 - Lower gastrointestinal tract cancer predisposition syndromes

AU - Shah, Neel B.

AU - Lindor, Noralane M.

PY - 2010/12

Y1 - 2010/12

N2 - Although inherited predisposition to colorectal cancer (CRC) has been suspected for more than 100 years, definitive proof of Mendelian syndromes had to await maturation of molecular genetic technologies. Since the l980s, the genetics of several clinically distinct entities has been revealed. Five disorders that share a hereditary predisposition to CRC are reviewed in this article.

AB - Although inherited predisposition to colorectal cancer (CRC) has been suspected for more than 100 years, definitive proof of Mendelian syndromes had to await maturation of molecular genetic technologies. Since the l980s, the genetics of several clinically distinct entities has been revealed. Five disorders that share a hereditary predisposition to CRC are reviewed in this article.

KW - Cancer

KW - Colorectal

KW - Genetic syndrome

KW - Lower GI

KW - Risk

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U2 - 10.1016/j.hoc.2010.08.012

DO - 10.1016/j.hoc.2010.08.012

M3 - Review article

C2 - 21075290

AN - SCOPUS:78249232944

SN - 0889-8588

VL - 24

SP - 1229

EP - 1252

JO - Hematology/Oncology Clinics of North America

JF - Hematology/Oncology Clinics of North America

IS - 6

ER -

Lower gastrointestinal tract cancer predisposition syndromes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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