Low-rate nerve stimulation during regional ischemia in the diagnosis of muscle glycogenosis

Mauro Lomonaco; Margherita Milone; Enza Maria Valente; Luca Padua; Pietro Tonali

doi:10.1002/mus.880191204

Low-rate nerve stimulation during regional ischemia in the diagnosis of muscle glycogenosis

Mauro Lomonaco, Margherita Milone, Enza Maria Valente, Luca Padua, Pietro Tonali

Neurology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Five patients with muscle glycogenoses (Gly), 30 normal subjects (NS), and 52 disease controls received 3 Hz repetitive stimulation of the ulnar nerve for 4 min (P-LRNS) during regional ischemia and during normal circulation. During regional ischemia, the compound muscle action potential (CMAP) of NS showed 8.5% (SE: 1.0) facilitation after 1 min of P-LRNS and 4.8 ± 1.5% facilitation after 4 min. Gly showed 8.1 ± 1.0% facilitation after 1 min of P-LRNS but -58.6 ± 6.9% depression after 4 min of P-LRNS. During normal circulation, in 18 NS and 4 Gly tested, the facilitation detected after 1 min of P-LRNS was unchanged until the end of stimulation. Compared with the mean ± 2 SD of NS, individual values of CMAP depression were abnormal in all Gly patients already by the 3rd min of ischemic P-LRNS. Of disease controls, myasthenia gravis patients only showed a CMAP depression during ischemic P-LRNS which was distinguishable from that detected in Gly, being mainly induced by neuromuscular transmission block.

Original language	English (US)
Pages (from-to)	1523-1529
Number of pages	7
Journal	Muscle and Nerve
Volume	19
Issue number	12
DOIs	https://doi.org/10.1002/mus.880191204
State	Published - Dec 1996

Keywords

compound muscle action potential depression
compound muscle action potential facilitation
muscle glycogenosis
regional ischemia
repetitive nerve stimulation

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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10.1002/mus.880191204

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title = "Low-rate nerve stimulation during regional ischemia in the diagnosis of muscle glycogenosis",

abstract = "Five patients with muscle glycogenoses (Gly), 30 normal subjects (NS), and 52 disease controls received 3 Hz repetitive stimulation of the ulnar nerve for 4 min (P-LRNS) during regional ischemia and during normal circulation. During regional ischemia, the compound muscle action potential (CMAP) of NS showed 8.5% (SE: 1.0) facilitation after 1 min of P-LRNS and 4.8 ± 1.5% facilitation after 4 min. Gly showed 8.1 ± 1.0% facilitation after 1 min of P-LRNS but -58.6 ± 6.9% depression after 4 min of P-LRNS. During normal circulation, in 18 NS and 4 Gly tested, the facilitation detected after 1 min of P-LRNS was unchanged until the end of stimulation. Compared with the mean ± 2 SD of NS, individual values of CMAP depression were abnormal in all Gly patients already by the 3rd min of ischemic P-LRNS. Of disease controls, myasthenia gravis patients only showed a CMAP depression during ischemic P-LRNS which was distinguishable from that detected in Gly, being mainly induced by neuromuscular transmission block.",

keywords = "compound muscle action potential depression, compound muscle action potential facilitation, muscle glycogenosis, regional ischemia, repetitive nerve stimulation",

author = "Mauro Lomonaco and Margherita Milone and Valente, {Enza Maria} and Luca Padua and Pietro Tonali",

year = "1996",

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doi = "10.1002/mus.880191204",

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AU - Lomonaco, Mauro

AU - Milone, Margherita

AU - Valente, Enza Maria

AU - Padua, Luca

AU - Tonali, Pietro

PY - 1996/12

Y1 - 1996/12

N2 - Five patients with muscle glycogenoses (Gly), 30 normal subjects (NS), and 52 disease controls received 3 Hz repetitive stimulation of the ulnar nerve for 4 min (P-LRNS) during regional ischemia and during normal circulation. During regional ischemia, the compound muscle action potential (CMAP) of NS showed 8.5% (SE: 1.0) facilitation after 1 min of P-LRNS and 4.8 ± 1.5% facilitation after 4 min. Gly showed 8.1 ± 1.0% facilitation after 1 min of P-LRNS but -58.6 ± 6.9% depression after 4 min of P-LRNS. During normal circulation, in 18 NS and 4 Gly tested, the facilitation detected after 1 min of P-LRNS was unchanged until the end of stimulation. Compared with the mean ± 2 SD of NS, individual values of CMAP depression were abnormal in all Gly patients already by the 3rd min of ischemic P-LRNS. Of disease controls, myasthenia gravis patients only showed a CMAP depression during ischemic P-LRNS which was distinguishable from that detected in Gly, being mainly induced by neuromuscular transmission block.

AB - Five patients with muscle glycogenoses (Gly), 30 normal subjects (NS), and 52 disease controls received 3 Hz repetitive stimulation of the ulnar nerve for 4 min (P-LRNS) during regional ischemia and during normal circulation. During regional ischemia, the compound muscle action potential (CMAP) of NS showed 8.5% (SE: 1.0) facilitation after 1 min of P-LRNS and 4.8 ± 1.5% facilitation after 4 min. Gly showed 8.1 ± 1.0% facilitation after 1 min of P-LRNS but -58.6 ± 6.9% depression after 4 min of P-LRNS. During normal circulation, in 18 NS and 4 Gly tested, the facilitation detected after 1 min of P-LRNS was unchanged until the end of stimulation. Compared with the mean ± 2 SD of NS, individual values of CMAP depression were abnormal in all Gly patients already by the 3rd min of ischemic P-LRNS. Of disease controls, myasthenia gravis patients only showed a CMAP depression during ischemic P-LRNS which was distinguishable from that detected in Gly, being mainly induced by neuromuscular transmission block.

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KW - compound muscle action potential facilitation

KW - muscle glycogenosis

KW - regional ischemia

KW - repetitive nerve stimulation

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Low-rate nerve stimulation during regional ischemia in the diagnosis of muscle glycogenosis

Abstract

Keywords

ASJC Scopus subject areas

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