Low-rate nerve stimulation during regional ischemia in the diagnosis of muscle glycogenosis

Mauro Lomonaco, Margherita Milone, Enza Maria Valente, Luca Padua, Pietro Tonali

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Five patients with muscle glycogenoses (Gly), 30 normal subjects (NS), and 52 disease controls received 3 Hz repetitive stimulation of the ulnar nerve for 4 min (P-LRNS) during regional ischemia and during normal circulation. During regional ischemia, the compound muscle action potential (CMAP) of NS showed 8.5% (SE: 1.0) facilitation after 1 min of P-LRNS and 4.8 ± 1.5% facilitation after 4 min. Gly showed 8.1 ± 1.0% facilitation after 1 min of P-LRNS but -58.6 ± 6.9% depression after 4 min of P-LRNS. During normal circulation, in 18 NS and 4 Gly tested, the facilitation detected after 1 min of P-LRNS was unchanged until the end of stimulation. Compared with the mean ± 2 SD of NS, individual values of CMAP depression were abnormal in all Gly patients already by the 3rd min of ischemic P-LRNS. Of disease controls, myasthenia gravis patients only showed a CMAP depression during ischemic P-LRNS which was distinguishable from that detected in Gly, being mainly induced by neuromuscular transmission block.

Original languageEnglish (US)
Pages (from-to)1523-1529
Number of pages7
JournalMuscle and Nerve
Volume19
Issue number12
StatePublished - Dec 1996
Externally publishedYes

Fingerprint

Glycogen Storage Disease
Ischemia
Action Potentials
Muscles
Glycogen Storage Disease Type IV
Neuromuscular Blockade
Ulnar Nerve
Myasthenia Gravis

Keywords

  • compound muscle action potential depression
  • compound muscle action potential facilitation
  • muscle glycogenosis
  • regional ischemia
  • repetitive nerve stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Lomonaco, M., Milone, M., Valente, E. M., Padua, L., & Tonali, P. (1996). Low-rate nerve stimulation during regional ischemia in the diagnosis of muscle glycogenosis. Muscle and Nerve, 19(12), 1523-1529.

Low-rate nerve stimulation during regional ischemia in the diagnosis of muscle glycogenosis. / Lomonaco, Mauro; Milone, Margherita; Valente, Enza Maria; Padua, Luca; Tonali, Pietro.

In: Muscle and Nerve, Vol. 19, No. 12, 12.1996, p. 1523-1529.

Research output: Contribution to journalArticle

Lomonaco, M, Milone, M, Valente, EM, Padua, L & Tonali, P 1996, 'Low-rate nerve stimulation during regional ischemia in the diagnosis of muscle glycogenosis', Muscle and Nerve, vol. 19, no. 12, pp. 1523-1529.
Lomonaco, Mauro ; Milone, Margherita ; Valente, Enza Maria ; Padua, Luca ; Tonali, Pietro. / Low-rate nerve stimulation during regional ischemia in the diagnosis of muscle glycogenosis. In: Muscle and Nerve. 1996 ; Vol. 19, No. 12. pp. 1523-1529.
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