Low Plasma Omega-3 Fatty Acid Levels May Predict Inferior Prognosis in Untreated Diffuse Large B-Cell Lymphoma

A New Modifiable Dietary Biomarker?

Research output: Contribution to journalArticle

Abstract

Dietary factors that may reduce the risk of relapse or prolong remission are an area of interest for patients with cancer. There is little data on the role of omega-3 fatty acids (n-3 FA) in patients diagnosed with lymphoma. This pilot biomarker study evaluated the prognostic significance of n-3 FA levels in patients with diffuse large B-cell lymphoma (DLBCL). In this analysis, low n-3 FA may be associated with inferior event free survival at 24 months in this disease. Larger studies are needed to confirm this association and could provide the basis for prospective investigation of whether modifying n-3 levels with diet may improve outcome in lymphoma.

Original languageEnglish (US)
JournalNutrition and Cancer
DOIs
StateAccepted/In press - Jan 1 2018

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Lymphoma, Large B-Cell, Diffuse
Omega-3 Fatty Acids
Biomarkers
Lymphoma
Disease-Free Survival
Diet
Recurrence
Neoplasms

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

Cite this

@article{35bcf825c1dd4af9ab9b2e9159a1eaed,
title = "Low Plasma Omega-3 Fatty Acid Levels May Predict Inferior Prognosis in Untreated Diffuse Large B-Cell Lymphoma: A New Modifiable Dietary Biomarker?",
abstract = "Dietary factors that may reduce the risk of relapse or prolong remission are an area of interest for patients with cancer. There is little data on the role of omega-3 fatty acids (n-3 FA) in patients diagnosed with lymphoma. This pilot biomarker study evaluated the prognostic significance of n-3 FA levels in patients with diffuse large B-cell lymphoma (DLBCL). In this analysis, low n-3 FA may be associated with inferior event free survival at 24 months in this disease. Larger studies are needed to confirm this association and could provide the basis for prospective investigation of whether modifying n-3 levels with diet may improve outcome in lymphoma.",
author = "Gita Thanarajasingam and Maurer, {Matthew J.} and Habermann, {Thomas Matthew} and Nowakowski, {Grzegorz S} and Nabila Bennani and Thompson, {Carrie A} and Cerhan, {James R} and Witzig, {Thomas Elmer}",
year = "2018",
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day = "1",
doi = "10.1080/01635581.2018.1502328",
language = "English (US)",
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T2 - A New Modifiable Dietary Biomarker?

AU - Thanarajasingam, Gita

AU - Maurer, Matthew J.

AU - Habermann, Thomas Matthew

AU - Nowakowski, Grzegorz S

AU - Bennani, Nabila

AU - Thompson, Carrie A

AU - Cerhan, James R

AU - Witzig, Thomas Elmer

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N2 - Dietary factors that may reduce the risk of relapse or prolong remission are an area of interest for patients with cancer. There is little data on the role of omega-3 fatty acids (n-3 FA) in patients diagnosed with lymphoma. This pilot biomarker study evaluated the prognostic significance of n-3 FA levels in patients with diffuse large B-cell lymphoma (DLBCL). In this analysis, low n-3 FA may be associated with inferior event free survival at 24 months in this disease. Larger studies are needed to confirm this association and could provide the basis for prospective investigation of whether modifying n-3 levels with diet may improve outcome in lymphoma.

AB - Dietary factors that may reduce the risk of relapse or prolong remission are an area of interest for patients with cancer. There is little data on the role of omega-3 fatty acids (n-3 FA) in patients diagnosed with lymphoma. This pilot biomarker study evaluated the prognostic significance of n-3 FA levels in patients with diffuse large B-cell lymphoma (DLBCL). In this analysis, low n-3 FA may be associated with inferior event free survival at 24 months in this disease. Larger studies are needed to confirm this association and could provide the basis for prospective investigation of whether modifying n-3 levels with diet may improve outcome in lymphoma.

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