Low dose combined chemotherapy/radiotherapy in the management of locally advanced urethral squamous cell carcinoma

D. W. Johnson, J. F. Kessler, R. G. Ferrigni, J. D. Anderson

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The successful treatment of a patient with bulky squamous cell carcinoma of the urethra using low dose preoperative radiation therapy and concurrent chemotherapy is described. Dramatic rapid tumor response facilitated surgical resection of the remaining microscopic disease. This clinical behavior is remarkably similar to that seen with squamous cell carcinoma of the anal canal and esophagus when a similar regimen is used. At the latter tumor sites the successful use of combination radiotherapy and chemotherapy has reduced the morbidity of subsequent surgery, and in selected cases has obviated the need for a radical operation. Further investigation of such combination treatment is warranted for urethral carcinoma.

Original languageEnglish (US)
Pages (from-to)615-616
Number of pages2
JournalJournal of Urology
Volume141
Issue number3 I
StatePublished - 1989
Externally publishedYes

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Squamous Cell Carcinoma
Radiotherapy
Drug Therapy
Anal Canal
Urethra
Combination Drug Therapy
Esophagus
Neoplasms
Morbidity
Carcinoma
Therapeutics

ASJC Scopus subject areas

  • Urology

Cite this

Johnson, D. W., Kessler, J. F., Ferrigni, R. G., & Anderson, J. D. (1989). Low dose combined chemotherapy/radiotherapy in the management of locally advanced urethral squamous cell carcinoma. Journal of Urology, 141(3 I), 615-616.

Low dose combined chemotherapy/radiotherapy in the management of locally advanced urethral squamous cell carcinoma. / Johnson, D. W.; Kessler, J. F.; Ferrigni, R. G.; Anderson, J. D.

In: Journal of Urology, Vol. 141, No. 3 I, 1989, p. 615-616.

Research output: Contribution to journalArticle

Johnson, DW, Kessler, JF, Ferrigni, RG & Anderson, JD 1989, 'Low dose combined chemotherapy/radiotherapy in the management of locally advanced urethral squamous cell carcinoma', Journal of Urology, vol. 141, no. 3 I, pp. 615-616.
Johnson, D. W. ; Kessler, J. F. ; Ferrigni, R. G. ; Anderson, J. D. / Low dose combined chemotherapy/radiotherapy in the management of locally advanced urethral squamous cell carcinoma. In: Journal of Urology. 1989 ; Vol. 141, No. 3 I. pp. 615-616.
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