Low dose combined chemotherapy/radiotherapy in the management of locally advanced urethral squamous cell carcinoma

D. W. Johnson, J. F. Kessler, R. G. Ferrigni, J. D. Anderson

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The successful treatment of a patient with bulky squamous cell carcinoma of the urethra using low dose preoperative radiation therapy and concurrent chemotherapy is described. Dramatic rapid tumor response facilitated surgical resection of the remaining microscopic disease. This clinical behavior is remarkably similar to that seen with squamous cell carcinoma of the anal canal and esophagus when a similar regimen is used. At the latter tumor sites the successful use of combination radiotherapy and chemotherapy has reduced the morbidity of subsequent surgery, and in selected cases has obviated the need for a radical operation. Further investigation of such combination treatment is warranted for urethral carcinoma.

Original languageEnglish (US)
Pages (from-to)615-616
Number of pages2
JournalJournal of Urology
Volume141
Issue number3 I
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Urology

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