TY - JOUR
T1 - Loss of ability to work and ability to live independently in Parkinson's disease
AU - Jasinska-Myga, Barbara
AU - Heckman, Michael G.
AU - Wider, Christian
AU - Putzke, John D.
AU - Wszolek, Zbigniew K.
AU - Uitti, Ryan J.
N1 - Funding Information:
We are grateful to all patients for their collaborations. R.J.U. is partially supported by the NIH/NINDS P50-NS072187 and NIH/NINDS NS057567 , the research funding from Advanced Neuromodulation Systems, Inc ., and a gift from Carl Edward Bolch, Jr., and Susan Bass Bolch ( MCF #90052031/PAU #90052 ). Z.K.W. is partially supported by the NIH/NINDS 1RC2NS070276 , NS057567 , P50NS072187 , Mayo Clinic Florida (MCF) Research Committee CR programs ( MCF #90052030 ), and a gift from Carl Edward Bolch, Jr., and Susan Bass Bolch ( MCF #90052031/PAU #90052 ). B.J-M. was supported by the Robert and Clarice Smith Fellowship Program and partially by the Pacific Alzheimer Research Foundation (PARF) C06-01 grant. C.W. was supported by the Swiss Parkinson Foundation . B.J.-M. and C.W. worked on this project during their clinical research fellowship at the Mayo Clinic Florida.
PY - 2012/2
Y1 - 2012/2
N2 - Objective: Ability to work and live independently is of particular concern for patients with Parkinson's disease (PD). We studied a series of PD patients able to work or live independently at baseline, and evaluated potential risk factors for two separate outcomes: loss of ability to work and loss of ability to live independently. Methods: The series comprised 495 PD patients followed prospectively. Ability to work and ability to live independently were based on clinical interview and examination. Cox regression models adjusted for age and disease duration were used to evaluate associations of baseline characteristics with loss of ability to work and loss of ability to live independently. Results: Higher UPDRS dyskinesia score, UPDRS instability score, UPDRS total score, Hoehn and Yahr stage, and presence of intellectual impairment at baseline were all associated with increased risk of future loss of ability to work and loss of ability to live independently (P≤0.0033). Five years after initial visit, for patients ≤70 years of age with a disease duration ≤4 years at initial visit, 88% were still able to work and 90% to live independently. These estimates worsened as age and disease duration at initial visit increased; for patients >70 years of age with a disease duration >4 years, estimates at 5 years were 43% able to work and 57% able to live independently. Conclusions: The information provided in this study can offer useful information for PD patients in preparing for future ability to perform activities of daily living.
AB - Objective: Ability to work and live independently is of particular concern for patients with Parkinson's disease (PD). We studied a series of PD patients able to work or live independently at baseline, and evaluated potential risk factors for two separate outcomes: loss of ability to work and loss of ability to live independently. Methods: The series comprised 495 PD patients followed prospectively. Ability to work and ability to live independently were based on clinical interview and examination. Cox regression models adjusted for age and disease duration were used to evaluate associations of baseline characteristics with loss of ability to work and loss of ability to live independently. Results: Higher UPDRS dyskinesia score, UPDRS instability score, UPDRS total score, Hoehn and Yahr stage, and presence of intellectual impairment at baseline were all associated with increased risk of future loss of ability to work and loss of ability to live independently (P≤0.0033). Five years after initial visit, for patients ≤70 years of age with a disease duration ≤4 years at initial visit, 88% were still able to work and 90% to live independently. These estimates worsened as age and disease duration at initial visit increased; for patients >70 years of age with a disease duration >4 years, estimates at 5 years were 43% able to work and 57% able to live independently. Conclusions: The information provided in this study can offer useful information for PD patients in preparing for future ability to perform activities of daily living.
KW - Independence
KW - Parkinson disease
KW - Work ability
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U2 - 10.1016/j.parkreldis.2011.08.022
DO - 10.1016/j.parkreldis.2011.08.022
M3 - Article
C2 - 21975262
AN - SCOPUS:84856234320
SN - 1353-8020
VL - 18
SP - 130
EP - 135
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
IS - 2
ER -