Long-term follow-up of the DeKAF cross-sectional cohort study

Arthur J. Matas, Ann Fieberg, Roslyn B. Mannon, Robert Leduc, Joseph Peter Grande, Bertram L. Kasiske, Michael Cecka, Robert Gaston, Lawrence Hunsicker, John Connett, Fernando G Cosio, Sita Gourishankar, David Rush

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2 Scopus citations

Abstract

The DeKAF study was developed to better understand the causes of late allograft loss. Preliminary findings from the DeKAF cross-sectional cohort (with follow-up < 20 months) have been published. Herein, we present long-term outcomes in those recipients (mean follow-up ± SD, 6.6 ± 0.7 years). Eligibility included being transplanted prior to October 1, 2005; serum creatinine ≤ 2.0 mg/dL on January 1, 2006; and subsequently developing new-onset graft dysfunction leading to a biopsy. Mean time from transplant to biopsy was 7.5 ± 6.1 years. Histologic findings and DSA were studied in relation to postbiopsy outcomes. Long-term follow-up confirms and expands the preliminary results of each of 3 studies: (1) increasing inflammation in area of atrophy (irrespective of inflammation in nonscarred areas [Banff i]) was associated with increasingly worse postbiopsy death-censored graft survival; (2) hierarchical analysis based on Banff scores defined clusters (entities) that differed in long-term death-censored graft survival; and (3) C4d−/DSA− recipients had significantly better (and C4d+/DSA+ worse) death-censored graft survival than other groups. C4d+/DSA- and C4d−/DSA+ had similar intermediate death-censored graft survival. Clinical and histologic findings at the time of new-onset graft dysfunction define high- vs low-risk groups for long-term death-censored graft survival, even years posttransplant. These findings can help differentiate groups for potential intervention studies.

Original languageEnglish (US)
JournalAmerican Journal of Transplantation
DOIs
StateAccepted/In press - Jan 1 2019

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Keywords

  • antibody biology
  • chronic allograft nephropathy
  • classification systems: Banff classification
  • clinical research/practice
  • clinical trial
  • graft survival
  • kidney transplantation/nephrology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Matas, A. J., Fieberg, A., Mannon, R. B., Leduc, R., Grande, J. P., Kasiske, B. L., Cecka, M., Gaston, R., Hunsicker, L., Connett, J., Cosio, F. G., Gourishankar, S., & Rush, D. (Accepted/In press). Long-term follow-up of the DeKAF cross-sectional cohort study. American Journal of Transplantation. https://doi.org/10.1111/ajt.15204