Long-distance retrograde neurotrophic signaling

Charles L. Howe; William C. Mobley

doi:10.1016/j.conb.2005.01.010

Long-distance retrograde neurotrophic signaling

Charles L. Howe, William C. Mobley

Neurology

Research output: Contribution to journal › Review article › peer-review

147 Scopus citations

Abstract

The retrograde communication of neurotrophic signals from axon terminals to neuron cell bodies is crucial for neuron survival and plasticity. Several mechanisms have been proposed in the past, but recent evidence strongly supports the hypothesis that the retrograde propagation of self-regenerating signaling organelles, derived from the endocytosis of activated neurotrophin-bound receptor tyrosine kinases, is the primary mechanism responsible for this long-distance communication.

Original language	English (US)
Pages (from-to)	40-48
Number of pages	9
Journal	Current Opinion in Neurobiology
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/j.conb.2005.01.010
State	Published - Feb 2005

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.conb.2005.01.010

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abstract = "The retrograde communication of neurotrophic signals from axon terminals to neuron cell bodies is crucial for neuron survival and plasticity. Several mechanisms have been proposed in the past, but recent evidence strongly supports the hypothesis that the retrograde propagation of self-regenerating signaling organelles, derived from the endocytosis of activated neurotrophin-bound receptor tyrosine kinases, is the primary mechanism responsible for this long-distance communication.",

author = "Howe, {Charles L.} and Mobley, {William C.}",

note = "Funding Information: The authors are indebted to A Salehi and to J Valletta for their contributions to the design of . WC Mobley is supported by grants from the National Institutes of Health (NS24054, AG16999, NS38869), the Hillblom Foundation, the Adler Foundation, the Alzheimer's Association, and the Down Syndrome Research and Treatment Foundation. CL Howe is supported by the Herdrich Family Foundation and the National Multiple Sclerosis Society. Figure 1 ",

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N2 - The retrograde communication of neurotrophic signals from axon terminals to neuron cell bodies is crucial for neuron survival and plasticity. Several mechanisms have been proposed in the past, but recent evidence strongly supports the hypothesis that the retrograde propagation of self-regenerating signaling organelles, derived from the endocytosis of activated neurotrophin-bound receptor tyrosine kinases, is the primary mechanism responsible for this long-distance communication.

AB - The retrograde communication of neurotrophic signals from axon terminals to neuron cell bodies is crucial for neuron survival and plasticity. Several mechanisms have been proposed in the past, but recent evidence strongly supports the hypothesis that the retrograde propagation of self-regenerating signaling organelles, derived from the endocytosis of activated neurotrophin-bound receptor tyrosine kinases, is the primary mechanism responsible for this long-distance communication.

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Long-distance retrograde neurotrophic signaling

Abstract

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