Long-distance retrograde neurotrophic signaling

Charles L Howe, William C. Mobley

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

The retrograde communication of neurotrophic signals from axon terminals to neuron cell bodies is crucial for neuron survival and plasticity. Several mechanisms have been proposed in the past, but recent evidence strongly supports the hypothesis that the retrograde propagation of self-regenerating signaling organelles, derived from the endocytosis of activated neurotrophin-bound receptor tyrosine kinases, is the primary mechanism responsible for this long-distance communication.

Original languageEnglish (US)
Pages (from-to)40-48
Number of pages9
JournalCurrent Opinion in Neurobiology
Volume15
Issue number1
DOIs
StatePublished - Feb 2005

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Nerve Growth Factor Receptors
Neurons
Presynaptic Terminals
Endocytosis
Organelles
Protein-Tyrosine Kinases
Cell Body

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Long-distance retrograde neurotrophic signaling. / Howe, Charles L; Mobley, William C.

In: Current Opinion in Neurobiology, Vol. 15, No. 1, 02.2005, p. 40-48.

Research output: Contribution to journalArticle

Howe, Charles L ; Mobley, William C. / Long-distance retrograde neurotrophic signaling. In: Current Opinion in Neurobiology. 2005 ; Vol. 15, No. 1. pp. 40-48.
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