Localized herpes simplex lymphadenitis mimicking large-cell (Richter's) transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma

Lija Joseph, Margie A. Scott, Steven A. Schichman, Clive S. Zent

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

We report a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) who presented with rapid enlargement of a cervical lymph node due to localized herpes simplex lymphadenitis, which was clinically indistinguishable from large cell (Richter's) transformation. The diagnosis was made by excisional lymph node biopsy, which demonstrated CLL/SLL and zonal necrosis due to herpes simplex infection. The herpetic zone was surrounded by a brisk proliferation of immunoblasts. This case demonstrates the need for excisional biopsy and histologic examination of rapidly enlarging nodes in patients with CLL/SLL. The diagnosis of herpes simplex lymphadenitis in patients with CLL/SLL is especially important because, unlike large cell transformation, the infection usually responds well to treatment.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalAmerican journal of hematology
Volume68
Issue number4
DOIs
StatePublished - 2001

Keywords

  • CLL/SLL
  • Herpes simplex virus
  • Large cell (Richter's) transformation
  • Large cell lymphoma
  • Lymphadenitis

ASJC Scopus subject areas

  • Hematology

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