Abstract
We report a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) who presented with rapid enlargement of a cervical lymph node due to localized herpes simplex lymphadenitis, which was clinically indistinguishable from large cell (Richter's) transformation. The diagnosis was made by excisional lymph node biopsy, which demonstrated CLL/SLL and zonal necrosis due to herpes simplex infection. The herpetic zone was surrounded by a brisk proliferation of immunoblasts. This case demonstrates the need for excisional biopsy and histologic examination of rapidly enlarging nodes in patients with CLL/SLL. The diagnosis of herpes simplex lymphadenitis in patients with CLL/SLL is especially important because, unlike large cell transformation, the infection usually responds well to treatment.
Original language | English (US) |
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Pages (from-to) | 287-291 |
Number of pages | 5 |
Journal | American journal of hematology |
Volume | 68 |
Issue number | 4 |
DOIs | |
State | Published - 2001 |
Keywords
- CLL/SLL
- Herpes simplex virus
- Large cell (Richter's) transformation
- Large cell lymphoma
- Lymphadenitis
ASJC Scopus subject areas
- Hematology