Localization of lead in rat peripheral nerve by electron microscopy

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Abstract

Lead intoxication in rats reliably produces segmental demyelination. Following a single intravenous injection of radioactive lead, localization of tracer was observed sequentially by quantitative electron microscopical autoradiog‐raphy. The animals injected had been on a lead‐containing diet for 70 days; as a result, the blood‐nerve barrier was broken down and demyelination was proceeding. Six hours after a single dose, the lead was localized to the endoneurial space of the peroneal nerve, and 72 hours later, to the myelin membrane. Lead may exert a direct effect on the membrane and alter its stability both by altering the lipid content of the membrane and by directly interfering with the lamellar structure.

Original languageEnglish (US)
Pages (from-to)197-201
Number of pages5
JournalAnnals of neurology
Volume18
Issue number2
DOIs
StatePublished - Aug 1985

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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