Localization of lead in rat peripheral nerve by electron microscopy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Lead intoxication in rats reliably produces segmental demyelination. Following a single intravenous injection of radioactive lead, localization of tracer was observed sequentially by quantitative electron microscopical autoradiography. The animals injected had been on a lead-containing diet for 70 days; as a result, the blood-nerve barrier was broken down and demyelination was proceeding. Six hours after a single dose, the lead was localized to the endoneurial space of the peroneal nerve, and 72 hours later, to the myelin membrane. Lead may exert a direct effect on the membrane and alter its stability both by altering the lipid content of the membrane and by directly interfering with the lamellar structure.

Original languageEnglish (US)
Pages (from-to)197-201
Number of pages5
JournalAnnals of Neurology
Volume18
Issue number2
StatePublished - 1985

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Peripheral Nerves
Electron Microscopy
Demyelinating Diseases
Blood-Nerve Barrier
Peroneal Nerve
Membranes
Membrane Lipids
Myelin Sheath
Autoradiography
Intravenous Injections
Lead
Electrons
Diet

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Localization of lead in rat peripheral nerve by electron microscopy. / Windebank, Anthony John; Dyck, Peter J.

In: Annals of Neurology, Vol. 18, No. 2, 1985, p. 197-201.

Research output: Contribution to journalArticle

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