Local delivery methods of therapeutic agents in the treatment of diffuse intrinsic brainstem gliomas

C. Rory Goodwin, Risheng Xu, Rajiv Iyer, Eric W. Sankey, Ann Liu, Nancy Abu-Bonsrah, Rachel Sarabia-Estrada, James L. Frazier, Daniel M. Sciubba, George I. Jallo

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Brainstem gliomas comprise 10-20% of all pediatric central nervous system (CNS) tumors and diffuse intrinsic pontine gliomas (DIPGs) account for the majority of these lesions. DIPG is a rapidly progressive disease with almost universally fatal outcomes and a median survival less than 12 months. Current standard-of-care treatment for DIPG includes radiation therapy, but its long-term survival effects are still under debate. Clinical trials investigating the efficacy of systemic administration of various therapeutic agents have been associated with disappointing outcomes. Recent efforts have focused on improvements in chemotherapeutic agents employed and in methods of localized and targeted drug delivery. This review provides an update on current preclinical and clinical studies investigating treatment options for brainstem gliomas.

Original languageEnglish (US)
Pages (from-to)120-127
Number of pages8
JournalClinical Neurology and Neurosurgery
Volume142
DOIs
StatePublished - Mar 2016

Keywords

  • Brainstem glioma
  • Chemotherapy
  • Convection-enhanced delivery
  • Interstitial continuous infusion
  • Intranasal deliverya
  • Tumor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Local delivery methods of therapeutic agents in the treatment of diffuse intrinsic brainstem gliomas'. Together they form a unique fingerprint.

  • Cite this

    Goodwin, C. R., Xu, R., Iyer, R., Sankey, E. W., Liu, A., Abu-Bonsrah, N., Sarabia-Estrada, R., Frazier, J. L., Sciubba, D. M., & Jallo, G. I. (2016). Local delivery methods of therapeutic agents in the treatment of diffuse intrinsic brainstem gliomas. Clinical Neurology and Neurosurgery, 142, 120-127. https://doi.org/10.1016/j.clineuro.2016.01.007