Local delivery methods of therapeutic agents in the treatment of diffuse intrinsic brainstem gliomas

C. Rory Goodwin, Risheng Xu, Rajiv Iyer, Eric W. Sankey, Ann Liu, Nancy Abu-Bonsrah, Rachel Sarabia Estrada, James L. Frazier, Daniel M. Sciubba, George I. Jallo

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Brainstem gliomas comprise 10-20% of all pediatric central nervous system (CNS) tumors and diffuse intrinsic pontine gliomas (DIPGs) account for the majority of these lesions. DIPG is a rapidly progressive disease with almost universally fatal outcomes and a median survival less than 12 months. Current standard-of-care treatment for DIPG includes radiation therapy, but its long-term survival effects are still under debate. Clinical trials investigating the efficacy of systemic administration of various therapeutic agents have been associated with disappointing outcomes. Recent efforts have focused on improvements in chemotherapeutic agents employed and in methods of localized and targeted drug delivery. This review provides an update on current preclinical and clinical studies investigating treatment options for brainstem gliomas.

Original languageEnglish (US)
Pages (from-to)120-127
Number of pages8
JournalClinical Neurology and Neurosurgery
Volume142
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

Fingerprint

Glioma
Brain Stem
Therapeutics
Central Nervous System Neoplasms
Fatal Outcome
Standard of Care
Radiotherapy
Clinical Trials
Pediatrics
Pharmaceutical Preparations

Keywords

  • Brainstem glioma
  • Chemotherapy
  • Convection-enhanced delivery
  • Interstitial continuous infusion
  • Intranasal deliverya
  • Tumor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Local delivery methods of therapeutic agents in the treatment of diffuse intrinsic brainstem gliomas. / Goodwin, C. Rory; Xu, Risheng; Iyer, Rajiv; Sankey, Eric W.; Liu, Ann; Abu-Bonsrah, Nancy; Sarabia Estrada, Rachel; Frazier, James L.; Sciubba, Daniel M.; Jallo, George I.

In: Clinical Neurology and Neurosurgery, Vol. 142, 01.03.2016, p. 120-127.

Research output: Contribution to journalReview article

Goodwin, CR, Xu, R, Iyer, R, Sankey, EW, Liu, A, Abu-Bonsrah, N, Sarabia Estrada, R, Frazier, JL, Sciubba, DM & Jallo, GI 2016, 'Local delivery methods of therapeutic agents in the treatment of diffuse intrinsic brainstem gliomas', Clinical Neurology and Neurosurgery, vol. 142, pp. 120-127. https://doi.org/10.1016/j.clineuro.2016.01.007
Goodwin, C. Rory ; Xu, Risheng ; Iyer, Rajiv ; Sankey, Eric W. ; Liu, Ann ; Abu-Bonsrah, Nancy ; Sarabia Estrada, Rachel ; Frazier, James L. ; Sciubba, Daniel M. ; Jallo, George I. / Local delivery methods of therapeutic agents in the treatment of diffuse intrinsic brainstem gliomas. In: Clinical Neurology and Neurosurgery. 2016 ; Vol. 142. pp. 120-127.
@article{4c48388dc56f485a8fbf5bfefe46e4e4,
title = "Local delivery methods of therapeutic agents in the treatment of diffuse intrinsic brainstem gliomas",
abstract = "Brainstem gliomas comprise 10-20{\%} of all pediatric central nervous system (CNS) tumors and diffuse intrinsic pontine gliomas (DIPGs) account for the majority of these lesions. DIPG is a rapidly progressive disease with almost universally fatal outcomes and a median survival less than 12 months. Current standard-of-care treatment for DIPG includes radiation therapy, but its long-term survival effects are still under debate. Clinical trials investigating the efficacy of systemic administration of various therapeutic agents have been associated with disappointing outcomes. Recent efforts have focused on improvements in chemotherapeutic agents employed and in methods of localized and targeted drug delivery. This review provides an update on current preclinical and clinical studies investigating treatment options for brainstem gliomas.",
keywords = "Brainstem glioma, Chemotherapy, Convection-enhanced delivery, Interstitial continuous infusion, Intranasal deliverya, Tumor",
author = "Goodwin, {C. Rory} and Risheng Xu and Rajiv Iyer and Sankey, {Eric W.} and Ann Liu and Nancy Abu-Bonsrah and {Sarabia Estrada}, Rachel and Frazier, {James L.} and Sciubba, {Daniel M.} and Jallo, {George I.}",
year = "2016",
month = "3",
day = "1",
doi = "10.1016/j.clineuro.2016.01.007",
language = "English (US)",
volume = "142",
pages = "120--127",
journal = "Clinical Neurology and Neurosurgery",
issn = "0303-8467",
publisher = "Elsevier",

}

TY - JOUR

T1 - Local delivery methods of therapeutic agents in the treatment of diffuse intrinsic brainstem gliomas

AU - Goodwin, C. Rory

AU - Xu, Risheng

AU - Iyer, Rajiv

AU - Sankey, Eric W.

AU - Liu, Ann

AU - Abu-Bonsrah, Nancy

AU - Sarabia Estrada, Rachel

AU - Frazier, James L.

AU - Sciubba, Daniel M.

AU - Jallo, George I.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Brainstem gliomas comprise 10-20% of all pediatric central nervous system (CNS) tumors and diffuse intrinsic pontine gliomas (DIPGs) account for the majority of these lesions. DIPG is a rapidly progressive disease with almost universally fatal outcomes and a median survival less than 12 months. Current standard-of-care treatment for DIPG includes radiation therapy, but its long-term survival effects are still under debate. Clinical trials investigating the efficacy of systemic administration of various therapeutic agents have been associated with disappointing outcomes. Recent efforts have focused on improvements in chemotherapeutic agents employed and in methods of localized and targeted drug delivery. This review provides an update on current preclinical and clinical studies investigating treatment options for brainstem gliomas.

AB - Brainstem gliomas comprise 10-20% of all pediatric central nervous system (CNS) tumors and diffuse intrinsic pontine gliomas (DIPGs) account for the majority of these lesions. DIPG is a rapidly progressive disease with almost universally fatal outcomes and a median survival less than 12 months. Current standard-of-care treatment for DIPG includes radiation therapy, but its long-term survival effects are still under debate. Clinical trials investigating the efficacy of systemic administration of various therapeutic agents have been associated with disappointing outcomes. Recent efforts have focused on improvements in chemotherapeutic agents employed and in methods of localized and targeted drug delivery. This review provides an update on current preclinical and clinical studies investigating treatment options for brainstem gliomas.

KW - Brainstem glioma

KW - Chemotherapy

KW - Convection-enhanced delivery

KW - Interstitial continuous infusion

KW - Intranasal deliverya

KW - Tumor

UR - http://www.scopus.com/inward/record.url?scp=84957942657&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957942657&partnerID=8YFLogxK

U2 - 10.1016/j.clineuro.2016.01.007

DO - 10.1016/j.clineuro.2016.01.007

M3 - Review article

C2 - 26849840

AN - SCOPUS:84957942657

VL - 142

SP - 120

EP - 127

JO - Clinical Neurology and Neurosurgery

JF - Clinical Neurology and Neurosurgery

SN - 0303-8467

ER -