Liver transplantation for jejunoileal bypass-associated cirrhosis: Allograft histology in the setting of an intact bypassed limb

S. M. D'Souza-Gburek, K. P. Batts, G. A. Nikias, R. H. Wiesner, R. A F Krom

Research output: Contribution to journalArticle

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Abstract

Jejunoileal bypass (JIB) is a well known cause of steatohepatitis, which may, on occasion, progress to cirrhosis and require liver transplantation. We report 3 patients who underwent orthotopic liver transplantation (OLT) for steatohepatitic cirrhosis secondary to JIB in which the JIB was left intact. All 3 patients have demonstrated recurrent steatosis in the graft after liver transplantation. In two of the cases, the changes are moderately severe, whereas in one case the changes are mild. All 3 patients have essentially normal liver function tests and are clinically asymptomatic; 1 of the patients has undergone removal of the JIB 2.5 years after transplantation. Control hepatic allografts in patients with primary biliary cirrhosis and primary sclerosing cholangitis show negligible fatty change, and in patients who receive transplants for alcoholic steatohepatitis, they rarely (2 of 20 patients) contain greater than 10% fat. We conclude that transplantation alone is not associated with subsequent steatosis. Presence of JIB is, therefore, a continuing risk factor for steatosis in patients who have undergone OLT. Reversal of JIB after OLT may be considered if fatty changes are severe or associated with significant fibrosis.

Original languageEnglish (US)
Pages (from-to)23-27
Number of pages5
JournalLiver Transplantation and Surgery
Volume3
Issue number1
StatePublished - 1997

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Jejunoileal Bypass
Liver Transplantation
Allografts
Histology
Fibrosis
Extremities
Transplantation
Alcoholic Fatty Liver
Transplants
Sclerosing Cholangitis
Biliary Liver Cirrhosis
Liver Function Tests
Fatty Liver
Fats
Liver

ASJC Scopus subject areas

  • Hepatology
  • Surgery

Cite this

D'Souza-Gburek, S. M., Batts, K. P., Nikias, G. A., Wiesner, R. H., & Krom, R. A. F. (1997). Liver transplantation for jejunoileal bypass-associated cirrhosis: Allograft histology in the setting of an intact bypassed limb. Liver Transplantation and Surgery, 3(1), 23-27.

Liver transplantation for jejunoileal bypass-associated cirrhosis : Allograft histology in the setting of an intact bypassed limb. / D'Souza-Gburek, S. M.; Batts, K. P.; Nikias, G. A.; Wiesner, R. H.; Krom, R. A F.

In: Liver Transplantation and Surgery, Vol. 3, No. 1, 1997, p. 23-27.

Research output: Contribution to journalArticle

D'Souza-Gburek, S. M. ; Batts, K. P. ; Nikias, G. A. ; Wiesner, R. H. ; Krom, R. A F. / Liver transplantation for jejunoileal bypass-associated cirrhosis : Allograft histology in the setting of an intact bypassed limb. In: Liver Transplantation and Surgery. 1997 ; Vol. 3, No. 1. pp. 23-27.
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