Liver resection for non-colorectal, non-carcinoid, non-sarcoma metastases: A multicenter study

Guillaume Martel, Jeff Hawel, Janelle Rekman, Kristopher P. Croome, Kimberly Bertens, Fady K. Balaa, Roberto Hernandez-Alejandro

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: The role of liver resection for non-colorectal, non-neuroendocrine, non-sarcoma (NCNNNS) metastases is ill-defined. This study aimed to examine the oncologic outcomes of liver resection in such patients. Methods: A retrospective analysis of liver resection for NCNNNS metastases was performed at two large centers. Liver resection was offered selectively in patients with stable disease. Oncologic outcomes were examined using the Kaplan-Meier method. Results: Fifty-two patients underwent liver resection for NCNNNS metastases. Overall 5-year survival was 58%. Five-year survival was 85% for breast metastases, 66% for ocular melanoma, 83% for other melanomas, 50% for gastro-esophageal metastases, and 0% for renal cell carcinoma metastases. A contemporary colorectal liver metastasis cohort had a survival of 63% (p=0.89). Conclusions: Liver resection is an effective option in the management of selected patients with NCNNNS metastases which have been deemed stable. Five-year survival rates were comparable to that of a contemporary cohort of patients with colorectal liver metastases in carefully selected patients. Further, larger studies are required to help identify potential prognostic variables and aid in decision-making in this heterogeneous population.

Original languageEnglish (US)
Article numbere0120569
JournalPLoS One
Volume10
Issue number3
DOIs
StatePublished - Mar 26 2015
Externally publishedYes

Fingerprint

resection
metastasis
Liver
Multicenter Studies
Neoplasm Metastasis
liver
melanoma
Survival
Melanoma
kidney cells
Renal Cell Carcinoma
breasts
carcinoma
decision making
Decision making
Decision Making
Cells
Breast
Survival Rate
eyes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Martel, G., Hawel, J., Rekman, J., Croome, K. P., Bertens, K., Balaa, F. K., & Hernandez-Alejandro, R. (2015). Liver resection for non-colorectal, non-carcinoid, non-sarcoma metastases: A multicenter study. PLoS One, 10(3), [e0120569]. https://doi.org/10.1371/journal.pone.0120569

Liver resection for non-colorectal, non-carcinoid, non-sarcoma metastases : A multicenter study. / Martel, Guillaume; Hawel, Jeff; Rekman, Janelle; Croome, Kristopher P.; Bertens, Kimberly; Balaa, Fady K.; Hernandez-Alejandro, Roberto.

In: PLoS One, Vol. 10, No. 3, e0120569, 26.03.2015.

Research output: Contribution to journalArticle

Martel, G, Hawel, J, Rekman, J, Croome, KP, Bertens, K, Balaa, FK & Hernandez-Alejandro, R 2015, 'Liver resection for non-colorectal, non-carcinoid, non-sarcoma metastases: A multicenter study', PLoS One, vol. 10, no. 3, e0120569. https://doi.org/10.1371/journal.pone.0120569
Martel G, Hawel J, Rekman J, Croome KP, Bertens K, Balaa FK et al. Liver resection for non-colorectal, non-carcinoid, non-sarcoma metastases: A multicenter study. PLoS One. 2015 Mar 26;10(3). e0120569. https://doi.org/10.1371/journal.pone.0120569
Martel, Guillaume ; Hawel, Jeff ; Rekman, Janelle ; Croome, Kristopher P. ; Bertens, Kimberly ; Balaa, Fady K. ; Hernandez-Alejandro, Roberto. / Liver resection for non-colorectal, non-carcinoid, non-sarcoma metastases : A multicenter study. In: PLoS One. 2015 ; Vol. 10, No. 3.
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