Liver involvement in kidney disease and vice versa

Karen Van Hoeve, Djalila Mekahli, Eva Morava-Kozicz, Elena Levtchenko, Peter Witters

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

The liver and kidneys are often similarly affected by a single disease. This is the case in metabolic, immunological, toxic, and infectious diseases, and in the different congenital malformation syndromes. Also, an enzymatic defect in an otherwise healthy liver or the consequences of advanced liver disease by itself can cause kidney disease as a secondary phenomenon. In this review, we describe numerous pathogenic mechanisms leading to dysfunction or malformations of the liver and kidneys in children. We encourage multidisciplinary management for optimal care. A combined liver–kidney transplantation is sometimes needed.

Original languageEnglish (US)
Pages (from-to)957-971
Number of pages15
JournalPediatric Nephrology
Volume33
Issue number6
DOIs
StatePublished - Jun 1 2018
Externally publishedYes

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Keywords

  • Combined kidney–liver transplantation
  • Kidney disease
  • Liver disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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