Liver and lung: Hepatopulmonary syndrome

Kenneth T. Yen, Michael Joseph Krowka, Augustine S. Lee, David J. Kramer, Charles Dwayne Burger

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hepatopulmonary syndrome (HPS) is characterized by the triad of hepatic dysfunction, arterial hypoxemia, and intrapulmonary vascular dilatations. Patients with HPS may have symptoms of liver disease rather than respiratory symptoms, but typical respiratory signs and symptoms include exertional dyspnea, platypnea, and orthodeoxia. Portal hypertension, cutaneous spider nevi, and digital clubbing are highly suggestive of HPS. The diagnostic workup includes arterial blood gas measurements, contrast-enhanced echocardiography, and technetium 99m-labeled macroaggregated albumin scanning. Pulmonary angiography may be necessary to detect discrete arteriovenous communications. Pharmacologic agents, such as almitrine bismesylate, prostaglandin F, indomethacin, somatostatin, and methylene blue, have been used to treat HPS, but results have been meager. Transjugular intrahepatic portosystemic shunt may improve oxygenation, and orthotopic liver transplantation may offer the best possibility for improvement.

Original languageEnglish (US)
Pages (from-to)309-315
Number of pages7
JournalJournal of Critical Illness
Volume17
Issue number8
StatePublished - Aug 2002

Fingerprint

Hepatopulmonary Syndrome
Lung
Liver
Respiratory Signs and Symptoms
Almitrine
Transjugular Intrahepatic Portasystemic Shunt
Spiders
Dinoprost
Nevus
Methylene Blue
Technetium
Portal Hypertension
Somatostatin
Indomethacin
Liver Transplantation
Dyspnea
Blood Vessels
Echocardiography
Liver Diseases
Dilatation

Keywords

  • Angiographic evidence of pattern defects
  • Clinical Conclusions
  • Clinical features
  • Intrapulmonary vascular dilatations
  • Treatment options

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Yen, K. T., Krowka, M. J., Lee, A. S., Kramer, D. J., & Burger, C. D. (2002). Liver and lung: Hepatopulmonary syndrome. Journal of Critical Illness, 17(8), 309-315.

Liver and lung : Hepatopulmonary syndrome. / Yen, Kenneth T.; Krowka, Michael Joseph; Lee, Augustine S.; Kramer, David J.; Burger, Charles Dwayne.

In: Journal of Critical Illness, Vol. 17, No. 8, 08.2002, p. 309-315.

Research output: Contribution to journalArticle

Yen, KT, Krowka, MJ, Lee, AS, Kramer, DJ & Burger, CD 2002, 'Liver and lung: Hepatopulmonary syndrome', Journal of Critical Illness, vol. 17, no. 8, pp. 309-315.
Yen, Kenneth T. ; Krowka, Michael Joseph ; Lee, Augustine S. ; Kramer, David J. ; Burger, Charles Dwayne. / Liver and lung : Hepatopulmonary syndrome. In: Journal of Critical Illness. 2002 ; Vol. 17, No. 8. pp. 309-315.
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