TY - JOUR
T1 - Lipoprotein-Associated Phospholipase A2
T2 - A Risk Marker or a Risk Factor?
AU - Lerman, Amir
AU - McConnell, Joseph P.
PY - 2008/6/16
Y1 - 2008/6/16
N2 - Multiple cardiovascular biomarkers are associated with increased cardiovascular disease (CVD) risk. Lipoprotein-associated phospholipase A2 (Lp-PLA2) appears to be relatively unique in its high specificity for and the causal pathway of plaque inflammation. In both primary and secondary prevention study populations, Lp-PLA2 was consistently associated with higher cardiovascular risk, and the risk estimate appears to be relatively unaffected by adjustment for conventional CVD risk factors. Risk ratios were similar, whether the mass concentration or activity of the enzyme was measured. The purpose of this article is to review the evidence for the clinical utility of Lp-PLA2, both as a risk marker and as a risk factor involved in the causal pathway of plaque inflammation and the formation of rupture-prone plaque.
AB - Multiple cardiovascular biomarkers are associated with increased cardiovascular disease (CVD) risk. Lipoprotein-associated phospholipase A2 (Lp-PLA2) appears to be relatively unique in its high specificity for and the causal pathway of plaque inflammation. In both primary and secondary prevention study populations, Lp-PLA2 was consistently associated with higher cardiovascular risk, and the risk estimate appears to be relatively unaffected by adjustment for conventional CVD risk factors. Risk ratios were similar, whether the mass concentration or activity of the enzyme was measured. The purpose of this article is to review the evidence for the clinical utility of Lp-PLA2, both as a risk marker and as a risk factor involved in the causal pathway of plaque inflammation and the formation of rupture-prone plaque.
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U2 - 10.1016/j.amjcard.2008.04.014
DO - 10.1016/j.amjcard.2008.04.014
M3 - Article
C2 - 18549867
AN - SCOPUS:51749083479
SN - 0002-9149
VL - 101
SP - S11-S22
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 12 SUPPL.
ER -