Lipoprotein-Associated Phospholipase A2: A Risk Marker or a Risk Factor?

Amir Lerman, Joseph P. McConnell

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Multiple cardiovascular biomarkers are associated with increased cardiovascular disease (CVD) risk. Lipoprotein-associated phospholipase A2 (Lp-PLA2) appears to be relatively unique in its high specificity for and the causal pathway of plaque inflammation. In both primary and secondary prevention study populations, Lp-PLA2 was consistently associated with higher cardiovascular risk, and the risk estimate appears to be relatively unaffected by adjustment for conventional CVD risk factors. Risk ratios were similar, whether the mass concentration or activity of the enzyme was measured. The purpose of this article is to review the evidence for the clinical utility of Lp-PLA2, both as a risk marker and as a risk factor involved in the causal pathway of plaque inflammation and the formation of rupture-prone plaque.

Original languageEnglish (US)
Pages (from-to)S11-S22
JournalAmerican Journal of Cardiology
Volume101
Issue number12 SUPPL.
DOIs
StatePublished - Jun 16 2008

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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