TY - JOUR
T1 - Lipids and the pathogenesis of Alzheimer's disease
T2 - Is there a link?
AU - Mielke, M. M.
AU - Lyketsos, C. G.
N1 - Funding Information:
This work was supported in part by grants P01 AG05146 and R01 AG19825 from the National Institute of Aging.
PY - 2006/4
Y1 - 2006/4
N2 - Alzheimer's disease (AD) is a heterogeneous neurodegenerative disorder characterized pathologically by amyloid-beta plaques, neurofibrillary tangles and neuronal loss. Its fundamental cause(s) and the pathological cascades leading to clinical symptoms remain unknown. Lipids and lipid peroxidation products have important roles in the homeostasis of the central nervous system. As well, lipid transport genes and vascular changes associated with peripheral dyslipidemia have been associated with an increased risk of AD. The present review discusses ways in which lipids may be involved in the pathogenesis of AD-associated neurodegeneration through their roles as neuronal structural components, cell modulators, or second messengers. Given the many possibilities through which lipids may be directly involved in or contribute to the pathogenesis of AD, the use of lipids as biomarkers for disease progression is discussed, as are other avenues for future research.
AB - Alzheimer's disease (AD) is a heterogeneous neurodegenerative disorder characterized pathologically by amyloid-beta plaques, neurofibrillary tangles and neuronal loss. Its fundamental cause(s) and the pathological cascades leading to clinical symptoms remain unknown. Lipids and lipid peroxidation products have important roles in the homeostasis of the central nervous system. As well, lipid transport genes and vascular changes associated with peripheral dyslipidemia have been associated with an increased risk of AD. The present review discusses ways in which lipids may be involved in the pathogenesis of AD-associated neurodegeneration through their roles as neuronal structural components, cell modulators, or second messengers. Given the many possibilities through which lipids may be directly involved in or contribute to the pathogenesis of AD, the use of lipids as biomarkers for disease progression is discussed, as are other avenues for future research.
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U2 - 10.1080/09540260600583007
DO - 10.1080/09540260600583007
M3 - Review article
C2 - 16777671
AN - SCOPUS:33646934160
SN - 0954-0261
VL - 18
SP - 173
EP - 186
JO - International Review of Psychiatry
JF - International Review of Psychiatry
IS - 2
ER -