LINGO1 rs9652490 is associated with essential tremor and Parkinson disease

Carles Vilariño-Güell, Owen A. Ross, Christian Wider, Barbara Jasinska-Myga, Stephanie A. Cobb, Alexandra I. Soto-Ortolaza, Jennifer M. Kachergus, Brett H. Keeling, Justus C. Dachsel, Heather L. Melrose, Bahareh Behrouz, Zbigniew K. Wszolek, Ryan J. Uitti, Jan O. Aasly, Alex Rajput, Matthew J. Farrer

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Recently, a variant in LINGO1 (rs9652490) was found to associate with increased risk of essential tremor. We set out to replicate this association in an independent case-control series of essential tremor from North America. In addition, given the clinical and pathological overlap between essential tremor and Parkinson disease, we also evaluate the effect of LINGO1 rs9652490 in two case-control series of Parkinson disease. Our study demonstrates a significant association between LINGO1 rs9652490 and essential tremor (P = 0.014) and Parkinson disease (P = 0.0003), thus providing the first evidence of a genetic link between both diseases.

Original languageEnglish (US)
Pages (from-to)109-111
Number of pages3
JournalParkinsonism and Related Disorders
Volume16
Issue number2
DOIs
StatePublished - Feb 1 2010

Keywords

  • Essential tremor
  • LINGO1
  • Parkinson-disease

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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    Vilariño-Güell, C., Ross, O. A., Wider, C., Jasinska-Myga, B., Cobb, S. A., Soto-Ortolaza, A. I., Kachergus, J. M., Keeling, B. H., Dachsel, J. C., Melrose, H. L., Behrouz, B., Wszolek, Z. K., Uitti, R. J., Aasly, J. O., Rajput, A., & Farrer, M. J. (2010). LINGO1 rs9652490 is associated with essential tremor and Parkinson disease. Parkinsonism and Related Disorders, 16(2), 109-111. https://doi.org/10.1016/j.parkreldis.2009.08.006