@article{38cb484a41ac4e559e24a0ee8f2e6cd3,
title = "LINGO1 rs9652490 is associated with essential tremor and Parkinson disease",
abstract = "Recently, a variant in LINGO1 (rs9652490) was found to associate with increased risk of essential tremor. We set out to replicate this association in an independent case-control series of essential tremor from North America. In addition, given the clinical and pathological overlap between essential tremor and Parkinson disease, we also evaluate the effect of LINGO1 rs9652490 in two case-control series of Parkinson disease. Our study demonstrates a significant association between LINGO1 rs9652490 and essential tremor (P = 0.014) and Parkinson disease (P = 0.0003), thus providing the first evidence of a genetic link between both diseases.",
keywords = "Essential tremor, LINGO1, Parkinson-disease",
author = "Carles Vilari{\~n}o-G{\"u}ell and Ross, {Owen A.} and Christian Wider and Barbara Jasinska-Myga and Cobb, {Stephanie A.} and Soto-Ortolaza, {Alexandra I.} and Kachergus, {Jennifer M.} and Keeling, {Brett H.} and Dachsel, {Justus C.} and Melrose, {Heather L.} and Bahareh Behrouz and Wszolek, {Zbigniew K.} and Uitti, {Ryan J.} and Aasly, {Jan O.} and Alex Rajput and Farrer, {Matthew J.}",
note = "Funding Information: The authors wish to thank the patients and families who participated in the study. This work was supported by the Parkinson's Disease Foundation, the Morris K. Udall Center, National Institute of Neurological Disorders and Stroke P50 NS40256 and The Mayo Foundation Research Committee, Essential Tremor: Clinical and Molecular Genetic Studies (CR program). ZKW is also partially funded by P01 AG017216, R01 NS057567, R01 AG015866 and CIHR 121849. Appendix ",
year = "2010",
month = feb,
doi = "10.1016/j.parkreldis.2009.08.006",
language = "English (US)",
volume = "16",
pages = "109--111",
journal = "Parkinsonism and Related Disorders",
issn = "1353-8020",
publisher = "Elsevier BV",
number = "2",
}