Linezolid is superior to vancomycin in experimental pneumonia caused by superantigen-producing Staphylococcus aureus in HLA class II transgenic mice

Melissa J. Karau, Ashenafi Y. Tilahun, Suzannah M. Schmidt, Chad R. Clark, Robin Patel, Govindarajan Rajagopalan

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Superantigens (SAg), the potent activators of the immune system, are important determinants of Staphylococcus aureus virulence and pathogenicity. Superior response to SAg in human leukocyte antigen (HLA)-DR3 transgenic mice rendered them more susceptible than C57BL/6 mice to pneumonia caused by SAg-producing strains of S. aureus. Linezolid, a bacterial protein synthesis inhibitor, was superior to vancomycin in inhibiting SAg production by S. aureus in vitro and conferred greater protection from pneumonia caused by SAg-producing staphylococci.

Original languageEnglish (US)
Pages (from-to)5401-5405
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume56
Issue number10
DOIs
StatePublished - Oct 2012

Fingerprint

Linezolid
Superantigens
Vancomycin
HLA Antigens
Transgenic Mice
Staphylococcus aureus
Pneumonia
Virulence
Protein Synthesis Inhibitors
Bacterial Proteins
Staphylococcus
Inbred C57BL Mouse
Immune System

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Linezolid is superior to vancomycin in experimental pneumonia caused by superantigen-producing Staphylococcus aureus in HLA class II transgenic mice. / Karau, Melissa J.; Tilahun, Ashenafi Y.; Schmidt, Suzannah M.; Clark, Chad R.; Patel, Robin; Rajagopalan, Govindarajan.

In: Antimicrobial Agents and Chemotherapy, Vol. 56, No. 10, 10.2012, p. 5401-5405.

Research output: Contribution to journalArticle

Karau, Melissa J. ; Tilahun, Ashenafi Y. ; Schmidt, Suzannah M. ; Clark, Chad R. ; Patel, Robin ; Rajagopalan, Govindarajan. / Linezolid is superior to vancomycin in experimental pneumonia caused by superantigen-producing Staphylococcus aureus in HLA class II transgenic mice. In: Antimicrobial Agents and Chemotherapy. 2012 ; Vol. 56, No. 10. pp. 5401-5405.
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