TY - JOUR
T1 - Linezolid is superior to vancomycin in experimental pneumonia caused by superantigen-producing Staphylococcus aureus in HLA class II transgenic mice
AU - Karau, Melissa J.
AU - Tilahun, Ashenafi Y.
AU - Schmidt, Suzannah M.
AU - Clark, Chad R.
AU - Patel, Robin
AU - Rajagopalan, Govindarajan
PY - 2012/10
Y1 - 2012/10
N2 - Superantigens (SAg), the potent activators of the immune system, are important determinants of Staphylococcus aureus virulence and pathogenicity. Superior response to SAg in human leukocyte antigen (HLA)-DR3 transgenic mice rendered them more susceptible than C57BL/6 mice to pneumonia caused by SAg-producing strains of S. aureus. Linezolid, a bacterial protein synthesis inhibitor, was superior to vancomycin in inhibiting SAg production by S. aureus in vitro and conferred greater protection from pneumonia caused by SAg-producing staphylococci.
AB - Superantigens (SAg), the potent activators of the immune system, are important determinants of Staphylococcus aureus virulence and pathogenicity. Superior response to SAg in human leukocyte antigen (HLA)-DR3 transgenic mice rendered them more susceptible than C57BL/6 mice to pneumonia caused by SAg-producing strains of S. aureus. Linezolid, a bacterial protein synthesis inhibitor, was superior to vancomycin in inhibiting SAg production by S. aureus in vitro and conferred greater protection from pneumonia caused by SAg-producing staphylococci.
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U2 - 10.1128/AAC.01080-12
DO - 10.1128/AAC.01080-12
M3 - Article
C2 - 22850509
AN - SCOPUS:84866335431
SN - 0066-4804
VL - 56
SP - 5401
EP - 5405
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 10
ER -