Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide

Pamela Thompson, Vani Lakshminarayanan, Nitin T. Supekar, Judy M. Bradley, Peter A Cohen, Margreet A. Wolfert, Sandra J Gendler, Geert Jan Boons

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A strategy for the linear synthesis of a sialylated glycolipopeptide cancer vaccine candidate has been developed using a strategically designed sialyl-Tn building block and microwave-assisted solid-phase peptide synthesis. The glycolipopeptide elicited potent humoral and cellular immune responses. T-cells primed by such a vaccine candidate could be restimulated by tumor-associated MUC1.

Original languageEnglish (US)
Pages (from-to)10214-10217
Number of pages4
JournalChemical Communications
Volume51
Issue number50
DOIs
StatePublished - May 28 2015

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Synthetic Vaccines
Vaccines
Glycopeptides
Cancer Vaccines
T-cells
Peptides
Tumors
Microwaves

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys

Cite this

Thompson, P., Lakshminarayanan, V., Supekar, N. T., Bradley, J. M., Cohen, P. A., Wolfert, M. A., ... Boons, G. J. (2015). Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide. Chemical Communications, 51(50), 10214-10217. https://doi.org/10.1039/c5cc02199e

Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide. / Thompson, Pamela; Lakshminarayanan, Vani; Supekar, Nitin T.; Bradley, Judy M.; Cohen, Peter A; Wolfert, Margreet A.; Gendler, Sandra J; Boons, Geert Jan.

In: Chemical Communications, Vol. 51, No. 50, 28.05.2015, p. 10214-10217.

Research output: Contribution to journalArticle

Thompson, Pamela ; Lakshminarayanan, Vani ; Supekar, Nitin T. ; Bradley, Judy M. ; Cohen, Peter A ; Wolfert, Margreet A. ; Gendler, Sandra J ; Boons, Geert Jan. / Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide. In: Chemical Communications. 2015 ; Vol. 51, No. 50. pp. 10214-10217.
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