Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide

Pamela Thompson, Vani Lakshminarayanan, Nitin T. Supekar, Judy M. Bradley, Peter A Cohen, Margreet A. Wolfert, Sandra J Gendler, Geert Jan Boons

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

A strategy for the linear synthesis of a sialylated glycolipopeptide cancer vaccine candidate has been developed using a strategically designed sialyl-Tn building block and microwave-assisted solid-phase peptide synthesis. The glycolipopeptide elicited potent humoral and cellular immune responses. T-cells primed by such a vaccine candidate could be restimulated by tumor-associated MUC1.

Original languageEnglish (US)
Pages (from-to)10214-10217
Number of pages4
JournalChemical Communications
Volume51
Issue number50
DOIs
StatePublished - May 28 2015

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ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys

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