Lifestyle and genetic contributions to cognitive decline and hippocampal structure and function in healthy aging

John L. Woodard, Michael A. Sugarman, Kristy A. Nielson, J. Carson Smith, Michael Seidenberg, Sally Durgerian, Alissa Butts, Nathan Hantke, Melissa Lancaster, Monica A. Matthews, Stephen M. Rao

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Background: Engagement in cognitively stimulating activities (CA) and leisure time physical activity (PA) have been associated with maintaining cognitive performance and reducing the likelihood of cognitive decline in older adults. However, neural mechanisms underlying protective effects of these lifestyle behaviors are largely unknown. In the current study, we investigated the effect of self-reported PA and CA on hippocampal volume and semantic processing activation during a fame discrimination task, as measured by functional magnetic resonance imaging (fMRI). We also examined whether possession of the apolipoprotein E (APOE) ε4 allele could moderate the effect of PA or CA on hippocampal structure or function. Methods: Seventy-eight healthy, cognitively intact older adults underwent baseline neuropsychological assessment, hippocampal volume measurement via manually-traced structural MRI, and task-activated fMRI. Results: After 18 months, 27 participants declined by one standard deviation or more on follow-up neuropsychological testing. Logistic regression analyses revealed that CA alone or in combination with baseline hippocampal structure or functional activity did not predict the probability of cognitive decline. In contrast, PA interacted with APOE ε4 status such that engagement in PA reduced the risk of cognitive decline in APOE ε4 carriers only. Furthermore, the benefits of PA appeared to diminish with reduced functional activity or volume in the hippocampus. Conclusions: Our findings suggest that increased leisure time PA is associated with reduced probability of cognitive decline in persons who are at high risk for AD. The beneficial effects of PA in this group may be related to enhancement of the functional and structural integrity of the hippocampus.

Original languageEnglish (US)
Pages (from-to)436-446
Number of pages11
JournalCurrent Alzheimer Research
Volume9
Issue number4
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Fingerprint

Apolipoprotein E4
Life Style
Leisure Activities
Hippocampus
Magnetic Resonance Imaging
Semantics
Logistic Models
Alleles
Regression Analysis
Cognitive Dysfunction

Keywords

  • Apolipoprotein E
  • Cognitive activity
  • Cognitive decline
  • Functional magnetic resonance imaging
  • Hippocampus
  • Physical activity

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Woodard, J. L., Sugarman, M. A., Nielson, K. A., Smith, J. C., Seidenberg, M., Durgerian, S., ... Rao, S. M. (2012). Lifestyle and genetic contributions to cognitive decline and hippocampal structure and function in healthy aging. Current Alzheimer Research, 9(4), 436-446. https://doi.org/10.2174/156720512800492477

Lifestyle and genetic contributions to cognitive decline and hippocampal structure and function in healthy aging. / Woodard, John L.; Sugarman, Michael A.; Nielson, Kristy A.; Smith, J. Carson; Seidenberg, Michael; Durgerian, Sally; Butts, Alissa; Hantke, Nathan; Lancaster, Melissa; Matthews, Monica A.; Rao, Stephen M.

In: Current Alzheimer Research, Vol. 9, No. 4, 01.01.2012, p. 436-446.

Research output: Contribution to journalArticle

Woodard, JL, Sugarman, MA, Nielson, KA, Smith, JC, Seidenberg, M, Durgerian, S, Butts, A, Hantke, N, Lancaster, M, Matthews, MA & Rao, SM 2012, 'Lifestyle and genetic contributions to cognitive decline and hippocampal structure and function in healthy aging', Current Alzheimer Research, vol. 9, no. 4, pp. 436-446. https://doi.org/10.2174/156720512800492477
Woodard, John L. ; Sugarman, Michael A. ; Nielson, Kristy A. ; Smith, J. Carson ; Seidenberg, Michael ; Durgerian, Sally ; Butts, Alissa ; Hantke, Nathan ; Lancaster, Melissa ; Matthews, Monica A. ; Rao, Stephen M. / Lifestyle and genetic contributions to cognitive decline and hippocampal structure and function in healthy aging. In: Current Alzheimer Research. 2012 ; Vol. 9, No. 4. pp. 436-446.
@article{e814d50fbcd6447d8ed317709007de20,
title = "Lifestyle and genetic contributions to cognitive decline and hippocampal structure and function in healthy aging",
abstract = "Background: Engagement in cognitively stimulating activities (CA) and leisure time physical activity (PA) have been associated with maintaining cognitive performance and reducing the likelihood of cognitive decline in older adults. However, neural mechanisms underlying protective effects of these lifestyle behaviors are largely unknown. In the current study, we investigated the effect of self-reported PA and CA on hippocampal volume and semantic processing activation during a fame discrimination task, as measured by functional magnetic resonance imaging (fMRI). We also examined whether possession of the apolipoprotein E (APOE) ε4 allele could moderate the effect of PA or CA on hippocampal structure or function. Methods: Seventy-eight healthy, cognitively intact older adults underwent baseline neuropsychological assessment, hippocampal volume measurement via manually-traced structural MRI, and task-activated fMRI. Results: After 18 months, 27 participants declined by one standard deviation or more on follow-up neuropsychological testing. Logistic regression analyses revealed that CA alone or in combination with baseline hippocampal structure or functional activity did not predict the probability of cognitive decline. In contrast, PA interacted with APOE ε4 status such that engagement in PA reduced the risk of cognitive decline in APOE ε4 carriers only. Furthermore, the benefits of PA appeared to diminish with reduced functional activity or volume in the hippocampus. Conclusions: Our findings suggest that increased leisure time PA is associated with reduced probability of cognitive decline in persons who are at high risk for AD. The beneficial effects of PA in this group may be related to enhancement of the functional and structural integrity of the hippocampus.",
keywords = "Apolipoprotein E, Cognitive activity, Cognitive decline, Functional magnetic resonance imaging, Hippocampus, Physical activity",
author = "Woodard, {John L.} and Sugarman, {Michael A.} and Nielson, {Kristy A.} and Smith, {J. Carson} and Michael Seidenberg and Sally Durgerian and Alissa Butts and Nathan Hantke and Melissa Lancaster and Matthews, {Monica A.} and Rao, {Stephen M.}",
year = "2012",
month = "1",
day = "1",
doi = "10.2174/156720512800492477",
language = "English (US)",
volume = "9",
pages = "436--446",
journal = "Current Alzheimer Research",
issn = "1567-2050",
publisher = "Bentham Science Publishers B.V.",
number = "4",

}

TY - JOUR

T1 - Lifestyle and genetic contributions to cognitive decline and hippocampal structure and function in healthy aging

AU - Woodard, John L.

AU - Sugarman, Michael A.

AU - Nielson, Kristy A.

AU - Smith, J. Carson

AU - Seidenberg, Michael

AU - Durgerian, Sally

AU - Butts, Alissa

AU - Hantke, Nathan

AU - Lancaster, Melissa

AU - Matthews, Monica A.

AU - Rao, Stephen M.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Background: Engagement in cognitively stimulating activities (CA) and leisure time physical activity (PA) have been associated with maintaining cognitive performance and reducing the likelihood of cognitive decline in older adults. However, neural mechanisms underlying protective effects of these lifestyle behaviors are largely unknown. In the current study, we investigated the effect of self-reported PA and CA on hippocampal volume and semantic processing activation during a fame discrimination task, as measured by functional magnetic resonance imaging (fMRI). We also examined whether possession of the apolipoprotein E (APOE) ε4 allele could moderate the effect of PA or CA on hippocampal structure or function. Methods: Seventy-eight healthy, cognitively intact older adults underwent baseline neuropsychological assessment, hippocampal volume measurement via manually-traced structural MRI, and task-activated fMRI. Results: After 18 months, 27 participants declined by one standard deviation or more on follow-up neuropsychological testing. Logistic regression analyses revealed that CA alone or in combination with baseline hippocampal structure or functional activity did not predict the probability of cognitive decline. In contrast, PA interacted with APOE ε4 status such that engagement in PA reduced the risk of cognitive decline in APOE ε4 carriers only. Furthermore, the benefits of PA appeared to diminish with reduced functional activity or volume in the hippocampus. Conclusions: Our findings suggest that increased leisure time PA is associated with reduced probability of cognitive decline in persons who are at high risk for AD. The beneficial effects of PA in this group may be related to enhancement of the functional and structural integrity of the hippocampus.

AB - Background: Engagement in cognitively stimulating activities (CA) and leisure time physical activity (PA) have been associated with maintaining cognitive performance and reducing the likelihood of cognitive decline in older adults. However, neural mechanisms underlying protective effects of these lifestyle behaviors are largely unknown. In the current study, we investigated the effect of self-reported PA and CA on hippocampal volume and semantic processing activation during a fame discrimination task, as measured by functional magnetic resonance imaging (fMRI). We also examined whether possession of the apolipoprotein E (APOE) ε4 allele could moderate the effect of PA or CA on hippocampal structure or function. Methods: Seventy-eight healthy, cognitively intact older adults underwent baseline neuropsychological assessment, hippocampal volume measurement via manually-traced structural MRI, and task-activated fMRI. Results: After 18 months, 27 participants declined by one standard deviation or more on follow-up neuropsychological testing. Logistic regression analyses revealed that CA alone or in combination with baseline hippocampal structure or functional activity did not predict the probability of cognitive decline. In contrast, PA interacted with APOE ε4 status such that engagement in PA reduced the risk of cognitive decline in APOE ε4 carriers only. Furthermore, the benefits of PA appeared to diminish with reduced functional activity or volume in the hippocampus. Conclusions: Our findings suggest that increased leisure time PA is associated with reduced probability of cognitive decline in persons who are at high risk for AD. The beneficial effects of PA in this group may be related to enhancement of the functional and structural integrity of the hippocampus.

KW - Apolipoprotein E

KW - Cognitive activity

KW - Cognitive decline

KW - Functional magnetic resonance imaging

KW - Hippocampus

KW - Physical activity

UR - http://www.scopus.com/inward/record.url?scp=84860527408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860527408&partnerID=8YFLogxK

U2 - 10.2174/156720512800492477

DO - 10.2174/156720512800492477

M3 - Article

C2 - 22272622

AN - SCOPUS:84860527408

VL - 9

SP - 436

EP - 446

JO - Current Alzheimer Research

JF - Current Alzheimer Research

SN - 1567-2050

IS - 4

ER -