Leukocytosis as an important risk factor for arterial thrombosis in WHO-defined early/prefibrotic myelofibrosis: An international study of 264 patients

Veronika Buxhofer-Ausch, Heinz Gisslinger, Jürgen Thiele, Bettina Gisslinger, Hans Michael Kvasnicka, Leonhard Müllauer, Sophie Frantal, Alessandra Carobbio, Francesco Passamonti, Elisa Rumi, Marco Ruggeri, Francesco Rodeghiero, Maria L. Randi, Irene Bertozzi, Alessandro M. Vannucchi, Elisabetta Antonioli, Guido Finazzi, Naseema Gangat, Ayalew Tefferi, Tiziano Barbui

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

We aimed to determine risk factors for thrombotic events in early/prefibrotic myelofibrosis diagnosed according to the World Health Organization criteria. Multivariate Cox regression analysis was calculated on a total number of 264 patients derived from an international database. After a median follow-up of 6.28 years, 42 (15.9%) patients experienced arterial (n = 31) or venous thrombosis (n = 11). A higher leukocyte count correlated with an increased risk for total thrombosis and in particular, with an increased risk for arterial thrombosis (P = 0.005, HR 1.15 and P = 0.047, HR 1.12, respectively). A platelet count above 870 × 10 9/L was associated with a lower risk for total thrombosis and also for venous thrombosis (P = 0.022, HR 0.44 and P = 0.027, HR 0.19). Moreover, a lower hemoglobin level was associated with an increased risk for venous thrombosis (P = 0.007, HR 0.59). Our data indicate that leukocytosis is a prominent risk factor for thrombosis in early/prefibrotic MF.

Original languageEnglish (US)
Pages (from-to)669-672
Number of pages4
JournalAmerican journal of hematology
Volume87
Issue number7
DOIs
StatePublished - Jul 2012

ASJC Scopus subject areas

  • Hematology

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    Buxhofer-Ausch, V., Gisslinger, H., Thiele, J., Gisslinger, B., Kvasnicka, H. M., Müllauer, L., Frantal, S., Carobbio, A., Passamonti, F., Rumi, E., Ruggeri, M., Rodeghiero, F., Randi, M. L., Bertozzi, I., Vannucchi, A. M., Antonioli, E., Finazzi, G., Gangat, N., Tefferi, A., & Barbui, T. (2012). Leukocytosis as an important risk factor for arterial thrombosis in WHO-defined early/prefibrotic myelofibrosis: An international study of 264 patients. American journal of hematology, 87(7), 669-672. https://doi.org/10.1002/ajh.23217