TY - JOUR
T1 - Leptin, adiposity, and mortality
T2 - Results from the national health and nutrition examination survey III, 1988 to 1994
AU - Batsis, John A.
AU - Sahakyan, Karine R.
AU - Singh, Prachi
AU - Bartels, Stephen J.
AU - Somers, Virend K.
AU - Lopez-Jimenez, Francisco
N1 - Funding Information:
Grant Support: This work was supported in part by the Department of Medicine, Geisel School of Medicine at Dartmouth, and the Dartmouth Centers for Health and Aging.
Funding Information:
Potential Competing Interests: Dr Batsis receives funding from Health Resources Services Administration (grant no. UB4HP19206-01-00 ) for medical geriatric teaching, the Junior Faculty Career Development Award, the Department of Medicine, Dartmouth-Hitchcock Medical Center, and the Dartmouth Centers for Health and Aging. Dr Sahakyan receives funding from the National Institutes of Health (grant no. HL00711-36 ). Dr Bartels receives funding from the National Institute of Mental Health (grant nos. K12 HS0217695 [Agency for Healthcare Research & Quality]; National Institute of Mental Health: T32 MH073553 , R01 MH078052 , R01 MH089811 , and R24 MH102794 ). Dr Singh receives the American Heart Association Scientist Development Grant (grant no. 11SDG7260046 ). Dr Somers receives funding from the National Heart, Lung, and Blood Institute (grant nos. R01 HL114676-02 , R01 HL114024-03 , and R01 HL065176-12 ). The sponsors had no role in the conduct and/or preparation, collection, analysis, and interpretation of the data; in writing of the report; and the decision to submit this manuscript.
Publisher Copyright:
© 2015 Mayo Foundation for Medical Education and Research.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Objective To determine whether leptin is related to all-cause and cardiovascular (CV) mortality in older adults. Patients and Methods Participants 60 years and older with plasma leptin level measurements from the National Health and Nutrition Examination Survey III (1988-1994) and mortality data linked to the National Death Index were included. We created sex-specific tertiles of leptin (men: 4.2-7.7 μg/L; women: 11.5-21.4 μg/L) to identify the effect of leptin on all-cause and CV mortality. We also determined whether leptin predicted mortality in patients with obesity. We classified obesity using 4 possible definitions: body mass index 30 kg/m2 or greater; body fat 25% or more in men and 35% or more in women; waist circumference 102 cm or greater in men and 88 cm or greater in women; and waist-hip ratio 0.85 or higher in women and 0.95 or higher in men. Sex-specific proportional hazard models were used to assess the effect of leptin on all-cause and CV mortality. Results Of 1794 participants, 51.6% were women; the mean age was 70.3±0.4 years, and the follow-up period was 12.5 years with 994 deaths (469 were CV deaths). All-cause mortality in the highest leptin tertile was significant neither in men (hazard ratio [HR], 1.23; 95% CI, 0.93-1.63) nor in women (HR, 0.97; 95% CI, 0.68-1.40). CV mortality was the highest in the highest leptin tertile in men (HR, 1.69; 95% CI, 1.06-2.70) but not in women (HR, 1.21; 95% CI, 0.73-1.98). Evaluating the effect of leptin in subgroups of different obesity definitions, we found that high leptin levels as predict CV mortality in men as measured by waist circumference or body fat. Conclusion Elevated leptin level is predictive of CV mortality only in men. Leptin may provide additional mortality discrimination in obese men.
AB - Objective To determine whether leptin is related to all-cause and cardiovascular (CV) mortality in older adults. Patients and Methods Participants 60 years and older with plasma leptin level measurements from the National Health and Nutrition Examination Survey III (1988-1994) and mortality data linked to the National Death Index were included. We created sex-specific tertiles of leptin (men: 4.2-7.7 μg/L; women: 11.5-21.4 μg/L) to identify the effect of leptin on all-cause and CV mortality. We also determined whether leptin predicted mortality in patients with obesity. We classified obesity using 4 possible definitions: body mass index 30 kg/m2 or greater; body fat 25% or more in men and 35% or more in women; waist circumference 102 cm or greater in men and 88 cm or greater in women; and waist-hip ratio 0.85 or higher in women and 0.95 or higher in men. Sex-specific proportional hazard models were used to assess the effect of leptin on all-cause and CV mortality. Results Of 1794 participants, 51.6% were women; the mean age was 70.3±0.4 years, and the follow-up period was 12.5 years with 994 deaths (469 were CV deaths). All-cause mortality in the highest leptin tertile was significant neither in men (hazard ratio [HR], 1.23; 95% CI, 0.93-1.63) nor in women (HR, 0.97; 95% CI, 0.68-1.40). CV mortality was the highest in the highest leptin tertile in men (HR, 1.69; 95% CI, 1.06-2.70) but not in women (HR, 1.21; 95% CI, 0.73-1.98). Evaluating the effect of leptin in subgroups of different obesity definitions, we found that high leptin levels as predict CV mortality in men as measured by waist circumference or body fat. Conclusion Elevated leptin level is predictive of CV mortality only in men. Leptin may provide additional mortality discrimination in obese men.
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U2 - 10.1016/j.mayocp.2015.01.023
DO - 10.1016/j.mayocp.2015.01.023
M3 - Article
C2 - 25841252
AN - SCOPUS:84926284025
VL - 90
SP - 481
EP - 491
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
SN - 0025-6196
IS - 4
ER -