TY - JOUR
T1 - Left ventricular function in subacute and chronic mitral regurgitation. Effect on function early postoperatively
AU - Kontos, G. J.
AU - Schaff, H. V.
AU - Gersh, B. J.
AU - Bove, A. A.
PY - 1989
Y1 - 1989
N2 - Quantitative analysis of biplane ventriculograms, including calculation of the end-systolic pressure/volume ratio, was used to define left ventricular systolic performance in 10 normal subjects, 10 patients with symptomatic subacute (< 6 months' duration) mitral regurgitation, and 18 patients with symptomatic chronic mitral regurgitation. Left ventricular volume, mass, and systolic function were similar for patients with subacute and with chronic mitral regurgitation, suggesting that some patients with recent-onset nonischemic mitral regurgitation have partial adaptation to chronic valve insufficiency prior to their symptomatic event. Rate of development of left ventricular wall stress in early systole was increased in subacute mitral regurgitation compared with chronic mitral regurgitation and normal subjects. Duration of symptoms did not correlate with degree of ventricular adaptation to mitral regurgitation, and end-systolic indices of left ventricular performance did not predict early postoperative clinical response to valve replacement or repair.
AB - Quantitative analysis of biplane ventriculograms, including calculation of the end-systolic pressure/volume ratio, was used to define left ventricular systolic performance in 10 normal subjects, 10 patients with symptomatic subacute (< 6 months' duration) mitral regurgitation, and 18 patients with symptomatic chronic mitral regurgitation. Left ventricular volume, mass, and systolic function were similar for patients with subacute and with chronic mitral regurgitation, suggesting that some patients with recent-onset nonischemic mitral regurgitation have partial adaptation to chronic valve insufficiency prior to their symptomatic event. Rate of development of left ventricular wall stress in early systole was increased in subacute mitral regurgitation compared with chronic mitral regurgitation and normal subjects. Duration of symptoms did not correlate with degree of ventricular adaptation to mitral regurgitation, and end-systolic indices of left ventricular performance did not predict early postoperative clinical response to valve replacement or repair.
UR - http://www.scopus.com/inward/record.url?scp=0024348451&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024348451&partnerID=8YFLogxK
U2 - 10.1016/s0022-5223(19)34406-x
DO - 10.1016/s0022-5223(19)34406-x
M3 - Article
C2 - 2755149
AN - SCOPUS:0024348451
SN - 0022-5223
VL - 98
SP - 163
EP - 169
JO - Journal of Thoracic and Cardiovascular Surgery
JF - Journal of Thoracic and Cardiovascular Surgery
IS - 2
ER -