Left ventricular flow analysis: Recent advances in numerical methods and applications in cardiac ultrasound

Iman Borazjani, John Westerdale, Eileen M. McMahon, Prathish K. Rajaraman, Jeffrey J. Heys, Marek Belohlavek

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

The left ventricle (LV) pumps oxygenated blood from the lungs to the rest of the body through systemic circulation. The efficiency of such a pumping function is dependent on blood flow within the LV chamber. It is therefore crucial to accurately characterize LV hemodynamics. Improved understanding of LV hemodynamics is expected to provide important clinical diagnostic and prognostic information. We review the recent advances in numerical and experimental methods for characterizing LV flows and focus on analysis of intraventricular flow fields by echocardiographic particle image velocimetry (echo-PIV), due to its potential for broad and practical utility. Future research directions to advance patient-specific LV simulations include development of methods capable of resolving heart valves, higher temporal resolution, automated generation of three-dimensional (3D) geometry, and incorporating actual flow measurements into the numerical solution of the 3D cardiovascular fluid dynamics.

Original languageEnglish (US)
Article number395081
JournalComputational and Mathematical Methods in Medicine
Volume2013
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Applied Mathematics

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