Left Atrial Size by Planimetry is Superior to M-mode Diameter: Biochemical Calibration by Atrial and Brain Natriuretic Peptide

Stefan Buchner, Michael Muscholl, Kurt Debl, Hans Werner Hense, Angela Döring, Jan Stritzke, Heribert Schunkert, Michihisa Jougasaki, John C Jr. Burnett, Günter A J Riegger, Andreas Luchner

Research output: Contribution to journalArticle

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Abstract

Background: Left atrial (LA) size is routinely assessed by M-mode on echocardiography. Recently, a superiority of apical measures of LA size has been suggested, but no biochemical calibration has been attempted yet. The aim of the current study was to compare echocardiographic parameters of LA size through biochemical calibration with the natriuretic peptides atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). Methods: A total of 610 middle-aged (50-67 years) subjects from a population-based sample (MONICA Augsburg, Germany) were characterized with respect to LA area and volume from the apical two-chamber (2C) and four-chamber (4C) views in addition to M-mode echocardiography. ANP and BNP concentrations were determined by radioimmunoassay. Results: A significant correlation to ANP and BNP was present with all measures on LA size. The univariate correlation was lowest with M-mode diameter (r = 0.11 with ANP; r = 0.09 with BNP, both P < .03), whereas 2C volume displayed the closest correlation (r = 0.20 with ANP and r = 0.28 with BNP, both P < .001) and even slightly exceeded 2C area, 4C volume, and 4C area. 2C volume further displaced LV systolic function, mass index, and heart rate as statistically significant predictors of ANP (P < .001) and BNP (P < .001) on adjusted regression analysis, whereas M-mode diameter was displaced as a significant predictor of ANP and BNP (P = not significant). Conclusions: The current population-based echocardiographic study allows new insight into the value of different measures of LA size. The closer association between natriuretic peptide concentrations and parameters derived from planimetry and volumetry suggests a superiority of these parameters LA diameter. LA volumetry should be included in routine echocardiography for optimized assessment of LA size.

Original languageEnglish (US)
Pages (from-to)380-385
Number of pages6
JournalJournal of the American Society of Echocardiography
Volume21
Issue number4
DOIs
StatePublished - Apr 2008

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Brain Natriuretic Peptide
Atrial Natriuretic Factor
Calibration
Echocardiography
Natriuretic Peptides
Population
Radioimmunoassay
Germany
Heart Rate
Regression Analysis
peptide P

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Left Atrial Size by Planimetry is Superior to M-mode Diameter : Biochemical Calibration by Atrial and Brain Natriuretic Peptide. / Buchner, Stefan; Muscholl, Michael; Debl, Kurt; Hense, Hans Werner; Döring, Angela; Stritzke, Jan; Schunkert, Heribert; Jougasaki, Michihisa; Burnett, John C Jr.; Riegger, Günter A J; Luchner, Andreas.

In: Journal of the American Society of Echocardiography, Vol. 21, No. 4, 04.2008, p. 380-385.

Research output: Contribution to journalArticle

Buchner, S, Muscholl, M, Debl, K, Hense, HW, Döring, A, Stritzke, J, Schunkert, H, Jougasaki, M, Burnett, JCJ, Riegger, GAJ & Luchner, A 2008, 'Left Atrial Size by Planimetry is Superior to M-mode Diameter: Biochemical Calibration by Atrial and Brain Natriuretic Peptide', Journal of the American Society of Echocardiography, vol. 21, no. 4, pp. 380-385. https://doi.org/10.1016/j.echo.2007.06.006
Buchner, Stefan ; Muscholl, Michael ; Debl, Kurt ; Hense, Hans Werner ; Döring, Angela ; Stritzke, Jan ; Schunkert, Heribert ; Jougasaki, Michihisa ; Burnett, John C Jr. ; Riegger, Günter A J ; Luchner, Andreas. / Left Atrial Size by Planimetry is Superior to M-mode Diameter : Biochemical Calibration by Atrial and Brain Natriuretic Peptide. In: Journal of the American Society of Echocardiography. 2008 ; Vol. 21, No. 4. pp. 380-385.
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abstract = "Background: Left atrial (LA) size is routinely assessed by M-mode on echocardiography. Recently, a superiority of apical measures of LA size has been suggested, but no biochemical calibration has been attempted yet. The aim of the current study was to compare echocardiographic parameters of LA size through biochemical calibration with the natriuretic peptides atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). Methods: A total of 610 middle-aged (50-67 years) subjects from a population-based sample (MONICA Augsburg, Germany) were characterized with respect to LA area and volume from the apical two-chamber (2C) and four-chamber (4C) views in addition to M-mode echocardiography. ANP and BNP concentrations were determined by radioimmunoassay. Results: A significant correlation to ANP and BNP was present with all measures on LA size. The univariate correlation was lowest with M-mode diameter (r = 0.11 with ANP; r = 0.09 with BNP, both P < .03), whereas 2C volume displayed the closest correlation (r = 0.20 with ANP and r = 0.28 with BNP, both P < .001) and even slightly exceeded 2C area, 4C volume, and 4C area. 2C volume further displaced LV systolic function, mass index, and heart rate as statistically significant predictors of ANP (P < .001) and BNP (P < .001) on adjusted regression analysis, whereas M-mode diameter was displaced as a significant predictor of ANP and BNP (P = not significant). Conclusions: The current population-based echocardiographic study allows new insight into the value of different measures of LA size. The closer association between natriuretic peptide concentrations and parameters derived from planimetry and volumetry suggests a superiority of these parameters LA diameter. LA volumetry should be included in routine echocardiography for optimized assessment of LA size.",
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T1 - Left Atrial Size by Planimetry is Superior to M-mode Diameter

T2 - Biochemical Calibration by Atrial and Brain Natriuretic Peptide

AU - Buchner, Stefan

AU - Muscholl, Michael

AU - Debl, Kurt

AU - Hense, Hans Werner

AU - Döring, Angela

AU - Stritzke, Jan

AU - Schunkert, Heribert

AU - Jougasaki, Michihisa

AU - Burnett, John C Jr.

AU - Riegger, Günter A J

AU - Luchner, Andreas

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N2 - Background: Left atrial (LA) size is routinely assessed by M-mode on echocardiography. Recently, a superiority of apical measures of LA size has been suggested, but no biochemical calibration has been attempted yet. The aim of the current study was to compare echocardiographic parameters of LA size through biochemical calibration with the natriuretic peptides atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). Methods: A total of 610 middle-aged (50-67 years) subjects from a population-based sample (MONICA Augsburg, Germany) were characterized with respect to LA area and volume from the apical two-chamber (2C) and four-chamber (4C) views in addition to M-mode echocardiography. ANP and BNP concentrations were determined by radioimmunoassay. Results: A significant correlation to ANP and BNP was present with all measures on LA size. The univariate correlation was lowest with M-mode diameter (r = 0.11 with ANP; r = 0.09 with BNP, both P < .03), whereas 2C volume displayed the closest correlation (r = 0.20 with ANP and r = 0.28 with BNP, both P < .001) and even slightly exceeded 2C area, 4C volume, and 4C area. 2C volume further displaced LV systolic function, mass index, and heart rate as statistically significant predictors of ANP (P < .001) and BNP (P < .001) on adjusted regression analysis, whereas M-mode diameter was displaced as a significant predictor of ANP and BNP (P = not significant). Conclusions: The current population-based echocardiographic study allows new insight into the value of different measures of LA size. The closer association between natriuretic peptide concentrations and parameters derived from planimetry and volumetry suggests a superiority of these parameters LA diameter. LA volumetry should be included in routine echocardiography for optimized assessment of LA size.

AB - Background: Left atrial (LA) size is routinely assessed by M-mode on echocardiography. Recently, a superiority of apical measures of LA size has been suggested, but no biochemical calibration has been attempted yet. The aim of the current study was to compare echocardiographic parameters of LA size through biochemical calibration with the natriuretic peptides atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). Methods: A total of 610 middle-aged (50-67 years) subjects from a population-based sample (MONICA Augsburg, Germany) were characterized with respect to LA area and volume from the apical two-chamber (2C) and four-chamber (4C) views in addition to M-mode echocardiography. ANP and BNP concentrations were determined by radioimmunoassay. Results: A significant correlation to ANP and BNP was present with all measures on LA size. The univariate correlation was lowest with M-mode diameter (r = 0.11 with ANP; r = 0.09 with BNP, both P < .03), whereas 2C volume displayed the closest correlation (r = 0.20 with ANP and r = 0.28 with BNP, both P < .001) and even slightly exceeded 2C area, 4C volume, and 4C area. 2C volume further displaced LV systolic function, mass index, and heart rate as statistically significant predictors of ANP (P < .001) and BNP (P < .001) on adjusted regression analysis, whereas M-mode diameter was displaced as a significant predictor of ANP and BNP (P = not significant). Conclusions: The current population-based echocardiographic study allows new insight into the value of different measures of LA size. The closer association between natriuretic peptide concentrations and parameters derived from planimetry and volumetry suggests a superiority of these parameters LA diameter. LA volumetry should be included in routine echocardiography for optimized assessment of LA size.

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