TY - JOUR
T1 - Left Atrial Appendage Occlusion for Stroke Prevention
AU - Alli, Oluseun
AU - Holmes, David R.
PY - 2012/10
Y1 - 2012/10
N2 - Atrial fibrillation (AF) remains the most common arrhythmia encountered in clinical practice. One of its most devastating complication is the development of thromboembolism leading to stroke. The left atrial appendage (LAA) has been shown to be the site of thrombus formation in the majority of strokes associated with AF. Anticoagulation with warfarin has been the treatment of choice for prevention of embolic events in these patients, but it does have significant limitations including bleeding, need for continued follow-up blood tests, and drug-drug interactions. Although newer anticoagulants have been developed, they still have the potential side effect of causing significant bleeding. Closure or exclusion of the LAA has emerged as an alternative therapeutic approach to medical therapy. The aim of this article is to review the anatomy and physiology of the LAA, discuss the various treatment strategies for stroke prevention, review the current devices and technologies available for LAA occlusion, and discuss some of the more recent data available on these technologies.
AB - Atrial fibrillation (AF) remains the most common arrhythmia encountered in clinical practice. One of its most devastating complication is the development of thromboembolism leading to stroke. The left atrial appendage (LAA) has been shown to be the site of thrombus formation in the majority of strokes associated with AF. Anticoagulation with warfarin has been the treatment of choice for prevention of embolic events in these patients, but it does have significant limitations including bleeding, need for continued follow-up blood tests, and drug-drug interactions. Although newer anticoagulants have been developed, they still have the potential side effect of causing significant bleeding. Closure or exclusion of the LAA has emerged as an alternative therapeutic approach to medical therapy. The aim of this article is to review the anatomy and physiology of the LAA, discuss the various treatment strategies for stroke prevention, review the current devices and technologies available for LAA occlusion, and discuss some of the more recent data available on these technologies.
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U2 - 10.1016/j.cpcardiol.2012.06.001
DO - 10.1016/j.cpcardiol.2012.06.001
M3 - Article
C2 - 23010100
AN - SCOPUS:84866618643
SN - 0146-2806
VL - 37
SP - 405
EP - 441
JO - Current Problems in Cardiology
JF - Current Problems in Cardiology
IS - 10
ER -