Left atrial appendage exclusion for atrial fibrillation

Faisal F. Syed, Christopher V. DeSimone, Paul A. Friedman, Samuel J. Asirvatham

Research output: Contribution to journalReview article

9 Scopus citations


Percutaneous left atrial appendage (LAA) closure is being increasingly used as a treatment strategy to prevent stroke in patients with atrial fibrillation (AF) who have contraindications to anticoagulants. Several approaches and devices have been developed in the last few years, each with their own unique set of advantages and disadvantages. In this article, the published studies on surgical and percutaneous approaches to LAA closure are reviewed, focusing on stroke mechanisms in AF, LAA structure and function relevant to stroke prevention, practical differences in procedural approach, and clinical considerations surrounding management.

Original languageEnglish (US)
Pages (from-to)601-625
Number of pages25
JournalCardiology clinics
Issue number4
StatePublished - 2014


  • Atrial fibrillation
  • Left atrial appendage
  • Percutaneous appendage closure
  • Stroke prevention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Left atrial appendage exclusion for atrial fibrillation'. Together they form a unique fingerprint.

  • Cite this