Learning and Memory Impairment in Older, Detoxified, Benzodiazepine-Dependent Patients

TERESA A. RUMMANS, LEO J. DAVIS, ROBERT M. MORSE, ROBERT J. IVNIK

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

The effects of benzodiazepine dependence on the ability to learn and remember new material (determined with the Auditory-Verbal Learning Test) were studied in 20 detoxified, benzodiazepine-dependent patients who were 55 years of age or older and in a drug-dependence rehabilitation program. The patients were matched approximately for age, sex, and IQ with 20 detoxified, alcohol-dependent patients in the same rehabilitation program and 22 control subjects from a community sample. Neuropsychologic testing was performed a mean of 6 to 10 days after the patients had been completely detoxified from the addicting substance. The benzodiazepine-dependent patients had more difficulty with tests of learning and short-term and delayed recall than did the alcohol-dependent or control group. The difference between the benzodiazepine-dependent patients and the control group was statistically significant. The results suggest that benzodiazepine dependence in older people can cause memory impairment that persists into the early drug-free period.

Original languageEnglish (US)
Pages (from-to)731-737
Number of pages7
JournalMayo Clinic proceedings
Volume68
Issue number8
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Medicine(all)

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    RUMMANS, TERESA. A., DAVIS, LEO. J., MORSE, ROBERT. M., & IVNIK, ROBERT. J. (1993). Learning and Memory Impairment in Older, Detoxified, Benzodiazepine-Dependent Patients. Mayo Clinic proceedings, 68(8), 731-737. https://doi.org/10.1016/S0025-6196(12)60628-4