Late-life time-restricted feeding and exercise differentially alter healthspan in obesity

Marissa J. Schafer, Daniel L. Mazula, Ashley K. Brown, Thomas A. White, Elizabeth Atkinson, Vesselina M. Pearsall, Zaira Aversa, Grace C. Verzosa, Leslie A. Smith, Aleksey V Matveyenko, Jordan D Miller, Nathan K LeBrasseur

Research output: Contribution to journalArticle

Abstract

Aging and obesity increase multimorbidity and disability risk, and determining interventions for reversing healthspan decline is a critical public health priority. Exercise and time-restricted feeding (TRF) benefit multiple health parameters when initiated in early life, but their efficacy and safety when initiated at older ages are uncertain. Here, we tested the effects of exercise versus TRF in diet-induced obese, aged mice from 20 to 24 months of age. We characterized healthspan across key domains: body composition, physical, metabolic, and cardiovascular function, activity of daily living (ADL) behavior, and pathology. We demonstrate that both exercise and TRF improved aspects of body composition. Exercise uniquely benefited physical function, and TRF uniquely benefited metabolism, ADL behavior, and circulating indicators of liver pathology. No adverse outcomes were observed in exercised mice, but in contrast, lean mass and cardiovascular maladaptations were observed following TRF. Through a composite index of benefits and risks, we conclude the net healthspan benefits afforded by exercise are more favorable than those of TRF. Extrapolating to obese older adults, exercise is a safe and effective option for healthspan improvement, but additional comprehensive studies are warranted before recommending TRF.

Original languageEnglish (US)
Article numbere12966
JournalAging Cell
Volume18
Issue number4
DOIs
StatePublished - Aug 1 2019

Fingerprint

Obesity
Activities of Daily Living
Body Composition
Pathology
Health Priorities
Obese Mice
Insurance Benefits
Comorbidity
Public Health
Diet
Safety
Liver

Keywords

  • aging
  • exercise
  • healthspan
  • obesity
  • physical activity
  • time-restricted feeding

ASJC Scopus subject areas

  • Aging
  • Cell Biology

Cite this

Schafer, M. J., Mazula, D. L., Brown, A. K., White, T. A., Atkinson, E., Pearsall, V. M., ... LeBrasseur, N. K. (2019). Late-life time-restricted feeding and exercise differentially alter healthspan in obesity. Aging Cell, 18(4), [e12966]. https://doi.org/10.1111/acel.12966

Late-life time-restricted feeding and exercise differentially alter healthspan in obesity. / Schafer, Marissa J.; Mazula, Daniel L.; Brown, Ashley K.; White, Thomas A.; Atkinson, Elizabeth; Pearsall, Vesselina M.; Aversa, Zaira; Verzosa, Grace C.; Smith, Leslie A.; Matveyenko, Aleksey V; Miller, Jordan D; LeBrasseur, Nathan K.

In: Aging Cell, Vol. 18, No. 4, e12966, 01.08.2019.

Research output: Contribution to journalArticle

Schafer, MJ, Mazula, DL, Brown, AK, White, TA, Atkinson, E, Pearsall, VM, Aversa, Z, Verzosa, GC, Smith, LA, Matveyenko, AV, Miller, JD & LeBrasseur, NK 2019, 'Late-life time-restricted feeding and exercise differentially alter healthspan in obesity', Aging Cell, vol. 18, no. 4, e12966. https://doi.org/10.1111/acel.12966
Schafer MJ, Mazula DL, Brown AK, White TA, Atkinson E, Pearsall VM et al. Late-life time-restricted feeding and exercise differentially alter healthspan in obesity. Aging Cell. 2019 Aug 1;18(4). e12966. https://doi.org/10.1111/acel.12966
Schafer, Marissa J. ; Mazula, Daniel L. ; Brown, Ashley K. ; White, Thomas A. ; Atkinson, Elizabeth ; Pearsall, Vesselina M. ; Aversa, Zaira ; Verzosa, Grace C. ; Smith, Leslie A. ; Matveyenko, Aleksey V ; Miller, Jordan D ; LeBrasseur, Nathan K. / Late-life time-restricted feeding and exercise differentially alter healthspan in obesity. In: Aging Cell. 2019 ; Vol. 18, No. 4.
@article{9d06576acf194d8ab469df4d11111222,
title = "Late-life time-restricted feeding and exercise differentially alter healthspan in obesity",
abstract = "Aging and obesity increase multimorbidity and disability risk, and determining interventions for reversing healthspan decline is a critical public health priority. Exercise and time-restricted feeding (TRF) benefit multiple health parameters when initiated in early life, but their efficacy and safety when initiated at older ages are uncertain. Here, we tested the effects of exercise versus TRF in diet-induced obese, aged mice from 20 to 24 months of age. We characterized healthspan across key domains: body composition, physical, metabolic, and cardiovascular function, activity of daily living (ADL) behavior, and pathology. We demonstrate that both exercise and TRF improved aspects of body composition. Exercise uniquely benefited physical function, and TRF uniquely benefited metabolism, ADL behavior, and circulating indicators of liver pathology. No adverse outcomes were observed in exercised mice, but in contrast, lean mass and cardiovascular maladaptations were observed following TRF. Through a composite index of benefits and risks, we conclude the net healthspan benefits afforded by exercise are more favorable than those of TRF. Extrapolating to obese older adults, exercise is a safe and effective option for healthspan improvement, but additional comprehensive studies are warranted before recommending TRF.",
keywords = "aging, exercise, healthspan, obesity, physical activity, time-restricted feeding",
author = "Schafer, {Marissa J.} and Mazula, {Daniel L.} and Brown, {Ashley K.} and White, {Thomas A.} and Elizabeth Atkinson and Pearsall, {Vesselina M.} and Zaira Aversa and Verzosa, {Grace C.} and Smith, {Leslie A.} and Matveyenko, {Aleksey V} and Miller, {Jordan D} and LeBrasseur, {Nathan K}",
year = "2019",
month = "8",
day = "1",
doi = "10.1111/acel.12966",
language = "English (US)",
volume = "18",
journal = "Aging Cell",
issn = "1474-9718",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Late-life time-restricted feeding and exercise differentially alter healthspan in obesity

AU - Schafer, Marissa J.

AU - Mazula, Daniel L.

AU - Brown, Ashley K.

AU - White, Thomas A.

AU - Atkinson, Elizabeth

AU - Pearsall, Vesselina M.

AU - Aversa, Zaira

AU - Verzosa, Grace C.

AU - Smith, Leslie A.

AU - Matveyenko, Aleksey V

AU - Miller, Jordan D

AU - LeBrasseur, Nathan K

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Aging and obesity increase multimorbidity and disability risk, and determining interventions for reversing healthspan decline is a critical public health priority. Exercise and time-restricted feeding (TRF) benefit multiple health parameters when initiated in early life, but their efficacy and safety when initiated at older ages are uncertain. Here, we tested the effects of exercise versus TRF in diet-induced obese, aged mice from 20 to 24 months of age. We characterized healthspan across key domains: body composition, physical, metabolic, and cardiovascular function, activity of daily living (ADL) behavior, and pathology. We demonstrate that both exercise and TRF improved aspects of body composition. Exercise uniquely benefited physical function, and TRF uniquely benefited metabolism, ADL behavior, and circulating indicators of liver pathology. No adverse outcomes were observed in exercised mice, but in contrast, lean mass and cardiovascular maladaptations were observed following TRF. Through a composite index of benefits and risks, we conclude the net healthspan benefits afforded by exercise are more favorable than those of TRF. Extrapolating to obese older adults, exercise is a safe and effective option for healthspan improvement, but additional comprehensive studies are warranted before recommending TRF.

AB - Aging and obesity increase multimorbidity and disability risk, and determining interventions for reversing healthspan decline is a critical public health priority. Exercise and time-restricted feeding (TRF) benefit multiple health parameters when initiated in early life, but their efficacy and safety when initiated at older ages are uncertain. Here, we tested the effects of exercise versus TRF in diet-induced obese, aged mice from 20 to 24 months of age. We characterized healthspan across key domains: body composition, physical, metabolic, and cardiovascular function, activity of daily living (ADL) behavior, and pathology. We demonstrate that both exercise and TRF improved aspects of body composition. Exercise uniquely benefited physical function, and TRF uniquely benefited metabolism, ADL behavior, and circulating indicators of liver pathology. No adverse outcomes were observed in exercised mice, but in contrast, lean mass and cardiovascular maladaptations were observed following TRF. Through a composite index of benefits and risks, we conclude the net healthspan benefits afforded by exercise are more favorable than those of TRF. Extrapolating to obese older adults, exercise is a safe and effective option for healthspan improvement, but additional comprehensive studies are warranted before recommending TRF.

KW - aging

KW - exercise

KW - healthspan

KW - obesity

KW - physical activity

KW - time-restricted feeding

UR - http://www.scopus.com/inward/record.url?scp=85068744856&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068744856&partnerID=8YFLogxK

U2 - 10.1111/acel.12966

DO - 10.1111/acel.12966

M3 - Article

VL - 18

JO - Aging Cell

JF - Aging Cell

SN - 1474-9718

IS - 4

M1 - e12966

ER -