Late Adult-Onset Metachromatic Leukodystrophy: Dementia and Polyneuropathy in a 63-Year-Old Man

E. Peter Bosch, Michael Noel Hart

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

A diagnosis of adult-onset metachromatic leukodystrophy (MLD) was established in a living 63-year-old man with progressive dementia and peripheral neuropathy. Decreased nerve conduction velocities and elevated spinal fluid protein concentration led to more specific diagnostic studies required to confirm the diagnosis. This case expands the spectrum of adult-onset MLD to patients with dementia and polyneuropathy past the sixth decade of life. Measurement of nerve conduction velocities may help to uncover cases of adult-onset MLD and should be included in the evaluation of dementia.

Original languageEnglish (US)
Pages (from-to)475-477
Number of pages3
JournalArchives of neurology
Volume35
Issue number7
DOIs
StatePublished - Jul 1978

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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