Large-vessel involvement in giant cell arteritis

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Purpose of review: Large-vessel involvement in giant cell arteritis occurs in over a quarter of patients with this disease. Stenosis of the primary and secondary branches of the aorta may cause claudication and tissue gangrene, whereas aortitis may lead to aneurysm formation and dissection, often many years after the initial diagnosis. Recent findings: Subsets of giant cell arteritis are probably caused by variations in the pathobiology of the disease. Radiographic imaging with some form of angiography is essential to reach a proper diagnosis. Although survival in giant cell arteritis is generally good, subsets of patients with aneurysm formation have a markedly diminished life expectancy. Glucocorticosteroids continue to be the mainstay of treatment for giant cell arteritis and its complications. Summary: Advances in diagnostic techniques including proteomic and genomic approaches should improve our understanding of the pathogenesis as well as the assessment of disease activity and extent. We provide a suggested algorithm for the evaluation of patients with large-vessel disease in giant cell arteritis.

Original languageEnglish (US)
Pages (from-to)10-17
Number of pages8
JournalCurrent Opinion in Rheumatology
Volume18
Issue number1
StatePublished - Jan 2006

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Giant Cell Arteritis
Aneurysm
Aortitis
Gangrene
Life Expectancy
Proteomics
Aorta
Dissection
Angiography
Pathologic Constriction
Survival

Keywords

  • Aneurysm
  • Giant cell arteritis
  • Large-vessel disease
  • Stenosis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Large-vessel involvement in giant cell arteritis. / Bongartz, Tim; Matteson, Eric Lawrence.

In: Current Opinion in Rheumatology, Vol. 18, No. 1, 01.2006, p. 10-17.

Research output: Contribution to journalArticle

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