TY - JOUR
T1 - Large-scale network balances in the transition from adaptive to maladaptive stress responses
AU - Homberg, Judith R.
AU - Kozicz, Tamas
AU - Fernández, Guillén
N1 - Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2017/4/1
Y1 - 2017/4/1
N2 - The stress response allows effective handling of threats, but can become maladaptive in vulnerable individuals causing anxiety. While research so far focused on individual brain regions, the field of human cognitive neuroscience emphasizes a brain organization in large-scale networks that support unique, broad cognitive domains. When threatened the balance between the salience and the executive control network is temporarily shifted towards the salience network allowing individuals to respond adequately, and re-balanced afterwards under the influence of glucocorticoids. Here we explore how risk factors like gender, early life adversity and genetics (5-HTTLPR) affect glucocorticoid release and associated network re-balancing. These risk factors set the balance towards the salience network, leading to insufficient matching to environmental demands and thereby anxiety.
AB - The stress response allows effective handling of threats, but can become maladaptive in vulnerable individuals causing anxiety. While research so far focused on individual brain regions, the field of human cognitive neuroscience emphasizes a brain organization in large-scale networks that support unique, broad cognitive domains. When threatened the balance between the salience and the executive control network is temporarily shifted towards the salience network allowing individuals to respond adequately, and re-balanced afterwards under the influence of glucocorticoids. Here we explore how risk factors like gender, early life adversity and genetics (5-HTTLPR) affect glucocorticoid release and associated network re-balancing. These risk factors set the balance towards the salience network, leading to insufficient matching to environmental demands and thereby anxiety.
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U2 - 10.1016/j.cobeha.2016.11.003
DO - 10.1016/j.cobeha.2016.11.003
M3 - Review article
AN - SCOPUS:84998673756
SN - 2352-1546
VL - 14
SP - 27
EP - 32
JO - Current Opinion in Behavioral Sciences
JF - Current Opinion in Behavioral Sciences
ER -